🏛️ Verified NIH Record • Updated 2026-06-29
Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease (NCT05022147)
ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: James Liao
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).
Who can join: Review the eligibility criteria below.
Location: Cleveland Clinic Foundation — Cleveland, Ohio
Age range: 21 Years
🧪 Interventions in This Study
- High-Frequency-Only Stimulation (DEVICE)
- Low-Frequency-Only Stimulation (DEVICE)
- Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation (DEVICE)
- Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation (DEVICE)
- Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation (DEVICE)
- Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation (DEVICE)
- OFF Dopaminergic Medication (DRUG)
- ON Dopaminergic Medication (DRUG)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Cleveland Clinic Foundation — Cleveland, Ohio
📞 Contact the Study Coordinator
Phone: (866) 223-8100
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Parkinson Disease
- Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation — Tucson, Arizona
- Parkinson's Disease Progression Study — Aurora, Colorado
- To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications — Birmingham, Alabama
- Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower) — Seattle, Washington
- Automated Imaging Differentiation of Parkinsonism — Birmingham, Alabama
- Study in Parkinson Disease of Exercise — Birmingham, Alabama
Explore by condition: All Parkinson Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.