Endometriosis and Microvascular Dysfunction: Role of Inflammation (NCT05069740)
Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Endometriosis
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (CV) risk. Circulating factors, low-density lipoprotein (LDL) and oxidized LDL (oxLDL), are two of many biomarkers of cardiovascular and inflammatory disease of endometriosis. An important signaling mechanism through which circulating LDL and oxLDL act is the lectin-like oxidized LDL receptor (LOX-1). LOX-1 signal transduction functionally results in pronounced endothelial dysfunction, a hallmark of CV. The investigators hypothesis that one factor mediating the elevated risk of cardiovascular disease in endometriosis is systemic inflammation and activation of LOX-1 receptor mechanisms.
Who can join: Review the eligibility criteria below.
Location: The Pennsylvania State University — University Park, Pennsylvania
Age range: 18 Years to 45 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- The Pennsylvania State University — University Park, Pennsylvania
📞 Contact the Study Coordinator
Phone: (814) 867-1781
Email: lma191@psu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Endometriosis
- Nutritional Intervention for Endometriosis — Washington D.C., District of Columbia
- Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI — Chapel Hill, North Carolina
- Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain — Anniston, Alabama
- The EMPOWER Study: Endometriosis Diagnosis Using MicroRNA — Palo Alto, California
- Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance — New Haven, Connecticut
- Endometriosis and Health Care System Utilization in British Columbia — Vancouver, British Columbia
Explore by condition: All Endometriosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.