🏛️ Verified NIH Record • Updated 2026-03-12
HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NCT05078034)
High-flow Nasal Oxygen With or Without Helmet Non-invasive Ventilation for Oxygenation Support in Acute Respiratory Failure (the HONOUR Pilot Trial)
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Sunnybrook Health Sciences Centre
🩺 Plain-English Summary (8th-Grade Level)
This Randomized Control Trial will directly compare helmet non-invasive ventilation (NIV) combined with high flow nasal oxygen (HFNO) versus HFNO alone in patients with Acute Hypoxemic Respiratory Failure (AHRF).
Who can join: Review the eligibility criteria below.
Location: University of Calgary — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- University of Calgary — Calgary, Alberta
- University of Alberta Hospital — Edmonton, Alberta
- Hamilton Health Sciences- Juravinski — Hamilton, Ontario
- Kingston General Hospital — Kingston, Ontario
- London Health Sciences Centre — London, Ontario
- Ottawa Hospital — Ottawa, Ontario
- North York General Hospital — Toronto, Ontario
- Sunnybrook Health Sciences Centre — Toronto, Ontario
- St. Michael's Hospital — Toronto, Ontario
- Mount Sinai Hospital — Toronto, Ontario
- University Health Network Toronto General — Toronto, Ontario
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Acute Hypoxemic Respiratory Failure
- Assessment of PaO2/FiO2 Ratio Pre and POst INTubation — Chicago, Illinois
- Adiposity Distribution in Acute Respiratory Failure — Boston, Massachusetts
- Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients — Chicago, Illinois
- Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation — Toronto, Ontario
- Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure — New York, New York
Explore by condition: All Acute Hypoxemic Respiratory Failure clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.