🏛️ Verified NIH Record • Updated 2026-04-15
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma (NCT05097287)
A Randomized, Double-Blind, Placebo Controlled Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Patients With Uncontrolled Moderate to Severe Asthma
🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Sanofi
🩺 Plain-English Summary (8th-Grade Level)
This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe asthma. The estimated duration is 4±1 weeks of screening and run-in period, followed by a 3-year double blinded treatment period. There will be a post-treatment follow-up (FU) period up to 12 weeks.
Who can join: Review the eligibility criteria below.
Location: Cullman Research Center- Site Number : 8400001 — Cullman, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (249 Sites)
Showing the first 25 of 249 sites.
- Cullman Research Center- Site Number : 8400001 — Cullman, Alabama
- Shoals Primary Care - Sheffield- Site Number : 8400015 — Sheffield, Alabama
- Chandler Clinical Research Trials- Site Number : 8400147 — Chandler, Arizona
- Pulmonary Associates - Deer Valley Office- Site Number : 8400155 — Phoenix, Arizona
- Medical Advancement Center of Arizona (MACOA)- Site Number : 8400130 — Phoenix, Arizona
- Del Sol Research Management - Tucson- Site Number : 8400017 — Tucson, Arizona
- Kern Allergy and Medical Research- Site Number : 8400037 — Bakersfield, California
- Vitality Clinical Research- Site Number : 8400142 — Beverly Hills, California
- Ascada Research - Fullerton- Site Number : 8400076 — Fullerton, California
- Allergy and Asthma Specialists Medical Group- Site Number : 8400162 — Huntington Beach, California
- Newport Native MD- Site Number : 8400054 — Newport Beach, California
- Prospective Research Innovations- Site Number : 8400131 — Rancho Cucamonga, California
- Mercy Medical Group - Midtown- Site Number : 8400164 — Sacramento, California
- Integrated Research of Inland- Site Number : 8400156 — Upland, California
- Allianz Research Institute- Site Number : 8400018 — Westminster, California
- Woodland Clinic - Woodland- Site Number : 8400171 — Woodland, California
- Central Florida Pulmonary Group - Altamonte Springs- Site Number : 8400035 — Altamonte Springs, Florida
- Florida Center for Allergy & Asthma Research- Site Number : 8400032 — Aventura, Florida
- Beautiful Minds Clinical Research Center- Site Number : 8400141 — Cutler Bay, Florida
- Omega Research Consultants - Debary - North Charles Richard Beall Boulevard- Site Number : 8400023 — DeBary, Florida
- Florida Lung, Asthma and Sleep Specialists (FLASS) - Polynesian- Site Number : 8400098 — Kissimmee, Florida
- Ivetmar Medical Group- Site Number : 8400063 — Miami, Florida
- My Preferred Research- Site Number : 8400073 — Miami, Florida
- Research Institute of South Florida- Site Number : 8400079 — Miami, Florida
- Floridian Clinical Research - Miami Lakes- Site Number : 8400091 — Miami Lakes, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Asthma
- Investigating Dupilumab's Effect in Asthma by Genotype — Boston, Massachusetts
- Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma — Bakersfield, California
- Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma — Saraland, Alabama
- Reduce IDentified UNcontrolled Asthma — San Diego, California
- A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma — Little Rock, Arkansas
- REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study — La Jolla, California
Explore by condition: All Asthma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.