Medrol Dosepak for Outpatient Total Knee Arthroplasty (NCT05097976)
An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper starting on postoperative day 1 (POD 1) following TKA will be associated with improved pain and decreased opioid use, nausea, and complications at POD1-7, as compared to similar patients who receive placebo. Additionally, those taking methylprednisolone will report decreased pain and greater objective functional outcomes at 3 and 6 weeks postoperatively as compared to controls.
Who can join: Review the eligibility criteria below.
Location: Rush Oak Brook Outpatient Center — Oak Brook, Illinois
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Rush Oak Brook Outpatient Center — Oak Brook, Illinois
📞 Contact the Study Coordinator
Phone: (312) 432-2468
Email: anne.debenedetti@rushortho.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Total Knee Arthroplasty
- Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty — Coon Rapids, Minnesota
- NitrX Total Knee Arthroplasty RSA — London, Ontario
- Bicruciate-retaining (2C) Total Knee Arthroplasty (TKA) Versus Posterior-stabilized (PS) Total Knee Arthroplasty (TKA) — Montreal, Quebec
- Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts — Edina, Minnesota
- Incidence of Adductor Canal Catheter Dislodgment — Toronto, Ontario
- IO Vancomycin Administration in TKA — San Diego, California
Explore by condition: All Total Knee Arthroplasty clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.