Abemaciclib (LY2835219) Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer (NCT05169567)
postMONARCH: A Randomized, Double Blind, Placebo-Controlled, Phase 3 Study to Compare the Efficacy of Abemaciclib Plus Fulvestrant to Placebo Plus Fulvestrant in Participants With HR+, HER2-, Advanced or Metastatic Breast Cancer Following Progression on a CDK4 & 6 Inhibitor and Endocrine Therapy
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the effect of adding abemaciclib to fulvestrant for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer that progressed or recurred after previous treatment with a type of drug known as a CDK4/6 inhibitor and endocrine therapy. Participation could last up to 5 years, depending on how you and your tumor respond.
Who can join: Review the eligibility criteria below.
Location: St. Joseph's Hospital and Medical Center — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (138 Sites)
Showing the first 25 of 138 sites.
- St. Joseph's Hospital and Medical Center — Phoenix, Arizona
- Highlands Oncology Group — Springdale, Arkansas
- Providence Medical Foundation — Fullerton, California
- Cancer and Blood Specialty Clinic — Los Alamitos, California
- TRIO-US (Translational Research in Oncology-US) — Los Angeles, California
- Keck School of Medicine of USC — Los Angeles, California
- UCLA Hematology/Oncology - Parkside — Santa Monica, California
- Olive View-UCLA Medical Center — Sylmar, California
- Torrance Memorial Physician Network / Cancer Care — Torrance, California
- PIH Health Hematology Medical Oncology — Whittier, California
- Rocky Mountain Cancer Center - Hale Parkway — Denver, Colorado
- Florida Cancer Specialists SOUTH/Sarah Cannon Research Institute/SCRI — Fort Myers, Florida
- Millennium Oncology Research Clinic — Hollywood, Florida
- University of Miami Hospital and Clinics, Sylvester Cancer Center — Miami, Florida
- Woodlands Medical Specialists, PA — Pensacola, Florida
- Florida Cancer Specialists SOUTH/Sarah Cannon Research Institute/SCRI — Sarasota, Florida
- Florida Cancer Specialists EAST/Sarah Cannon Research Institute/SCRI — West Palm Beach, Florida
- Winship Cancer Institute, Emory University — Atlanta, Georgia
- Northeast Georgia Medical Center — Gainesville, Georgia
- Central Georgia Cancer Care — Macon, Georgia
- Kapiolani Medical Center for Women and Children — Honolulu, Hawaii
- Ingalls Memorial Hospital — Harvey, Illinois
- Hematology Oncology Clinic- Baton Rouge/Sarah Cannon Research Institute/SCRI — Baton Rouge, Louisiana
- Clinical Trials of SWLA — Lake Charles, Louisiana
- Central Maine Medical Center — Lewiston, Maine
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.