🏛️ Verified NIH Record • Updated 2026-07-30
A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease (NCT05197049)
CNTO1959CRD3004: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab Subcutaneous Induction Therapy in Participants With Moderately to Severely Active Crohn's Disease
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.
Who can join: Review the eligibility criteria below.
Location: Digestive Health Specialists of the Southeast — Dothan, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (345 Sites)
Showing the first 25 of 345 sites.
- Digestive Health Specialists of the Southeast — Dothan, Alabama
- Advanced Gastro P.C — Chandler, Arizona
- Reliance Research — Scottsdale, Arizona
- Moore Clinical Trials, LLC — Little Rock, Arkansas
- Central Arkansas Veterans Healthcare System — Little Rock, Arkansas
- Om Research LLC 1 — Lancaster, California
- Om Research LLC — Lancaster, California
- United Gastroenterologists — Los Alamitos, California
- Paul Wallace MD — Los Angeles, California
- Clinnova Research — Orange, California
- Digestive System Healthcare — Pasadena, California
- Northshore Gastroenterology Research, LLC — San Diego, California
- Clinical Applications Laboratories, Inc — San Diego, California
- Santa Maria Gastroenterology — Santa Maria, California
- Clinical Research of California — Walnut Creek, California
- Amel Med LLC Research — Grand Junction, Colorado
- Western Connecticut Health Network/Danbury Hospital — Danbury, Connecticut
- Gastroenterology Associates of SW Florida — Clearwater, Florida
- Pioneer Research Solutions Inc. — Coconut Creek, Florida
- Omega Research Consultants — DeBary, Florida
- Harmony Medical Research Institute, Inc. — Hialeah, Florida
- Central Florida Gastro Research — Kissimmee, Florida
- Community Research Foundation, Inc. — Miami, Florida
- Gastroenterology Group Of Naples — Naples, Florida
- Center for Digestive Health — Orlando, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Crohn Disease
- Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E. Coli in Patients With Inactive Crohn's Disease — Lutherville, Maryland
- Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial — New Haven, Connecticut
- A Phase 2 Clinical Trial: Xanthohumol Metabolism and Signature (XMaS) in Crohn's Disease — Portland, Oregon
- Resistant Starch in Pediatric Inflammatory Bowel Disease (Crohn's Disease or Ulcerative Colitis) — Ottawa, Ontario
- A Long-term Extension Study of Ustekinumab in Pediatric Participants — Atlanta, Georgia
- Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease — Atlanta, Georgia
Explore by condition: All Crohn Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.