๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-27

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease (NCT05242471)

A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.

Who can join: Review the eligibility criteria below.

Location: University of Alabama Liver Center โ€” Birmingham, Alabama

Age range: 18 Years to 65 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (456 Sites)

Showing the first 25 of 456 sites.

  • University of Alabama Liver Center โ€” Birmingham, Alabama
  • Del Sol Research Management, LLC โ€” Tucson, Arizona
  • Moore Clinical Trials, LLC โ€” Little Rock, Arkansas
  • Om Research LLC โ€” Apple Valley, California
  • Valley Gastroenterology Medical Group โ€” Arcadia, California
  • Southern California Research Center โ€” Coronado, California
  • Desert Gastroenterology Associates โ€” Lancaster, California
  • Cedars Sinai Medical Center โ€” Los Angeles, California
  • UCLA โ€” Los Angeles, California
  • Hoag Memorial Hospital โ€” Newport Beach, California
  • UCI Irvine Medical Center โ€” Orange, California
  • Medical Associates Research Group, Inc. โ€” San Diego, California
  • University of California San Francisco โ€” San Francisco, California
  • University of Colorado โ€” Aurora, Colorado
  • Medical Research Center of Connecticut โ€” Hamden, Connecticut
  • Yale University School Of Medicine โ€” New Haven, Connecticut
  • MedStar Georgetown University Hospital โ€” Washington D.C., District of Columbia
  • Pioneer Research Solutions Inc. โ€” Coconut Creek, Florida
  • Homestead Associates in Research Inc โ€” Homestead, Florida
  • Osceola Mental Health D/B/A Park Place Behavioral Health Care โ€” Kissimmee, Florida
  • Florida Research Center Inc. โ€” Lakewood Rch, Florida
  • University of Miami Hospital โ€” Miami, Florida
  • Gastroenterology Group Of Naples โ€” Naples, Florida
  • Omega Research Consultants โ€” Orlando, Florida
  • Synergy Clinical Research โ€” St. Petersburg, Florida

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Crohn's Disease clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—