🏛️ Verified NIH Record • Updated 2026-08-27

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients (NCT06408935)

A Phase 3b, Open-label, Multicenter Study to Evaluate Transmural Healing and Disease Modifying Effect of Guselkumab in Crohn's Disease Patients

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Janssen-Cilag Ltd.

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan at Week 48.

Who can join: Review the eligibility criteria below.

Location: Center for Colitis and Crohns Disease University of California — San Francisco, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (84 Sites)

Showing the first 25 of 84 sites.

  • Center for Colitis and Crohns Disease University of California — San Francisco, California
  • The University of Chicago Medical Center (UCMC) — Chicago, Illinois
  • Washington University School Of Medicine — St Louis, Missouri
  • Medical University of South Carolina — Charleston, South Carolina
  • The Queen Elizabeth Hospital — Adelaide,
  • Concord Repatriation General Hospital — Concord,
  • Northern Hospital — Melbourne,
  • Fiona Stanley Hospital — Murdoch,
  • Mater Hospital Brisbane — South Brisbane,
  • AZ Maria Middelares — Ghent,
  • CHU de Liege — Liège,
  • Vitaz — Sint-Niklaas,
  • Cliged — Macaé,
  • Instituto Mederi de Pesquisa e Saude — Passo Fundo,
  • NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul — Porto Alegre,
  • INTEGRAL Pesquisa e Ensino — Votuporanga,
  • Foothills Hospital — Calgary, Alberta
  • Western University & London Health Sciences Centre — London, Ontario
  • Hopital du Sacre-Coeur de Montreal — Montreal, Quebec
  • Nemocnice Ceske Budejovice a s — České Budějovice,
  • Hepato-gastroenterologie HK, s.r.o. — Hradec Králové,
  • ISCARE a.s. — Prague,
  • CHU Amiens Picardie — Amiens,
  • CHU de Clermont Ferrand — Clermont-Ferrand,
  • CHRU de Lille Hopital Claude Huriez — Lille,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Crohn's Disease clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗