🏛️ Verified NIH Record • Updated 2026-08-27
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients (NCT06408935)
A Phase 3b, Open-label, Multicenter Study to Evaluate Transmural Healing and Disease Modifying Effect of Guselkumab in Crohn's Disease Patients
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Janssen-Cilag Ltd.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan at Week 48.
Who can join: Review the eligibility criteria below.
Location: Center for Colitis and Crohns Disease University of California — San Francisco, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (84 Sites)
Showing the first 25 of 84 sites.
- Center for Colitis and Crohns Disease University of California — San Francisco, California
- The University of Chicago Medical Center (UCMC) — Chicago, Illinois
- Washington University School Of Medicine — St Louis, Missouri
- Medical University of South Carolina — Charleston, South Carolina
- The Queen Elizabeth Hospital — Adelaide,
- Concord Repatriation General Hospital — Concord,
- Northern Hospital — Melbourne,
- Fiona Stanley Hospital — Murdoch,
- Mater Hospital Brisbane — South Brisbane,
- AZ Maria Middelares — Ghent,
- CHU de Liege — Liège,
- Vitaz — Sint-Niklaas,
- Cliged — Macaé,
- Instituto Mederi de Pesquisa e Saude — Passo Fundo,
- NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul — Porto Alegre,
- INTEGRAL Pesquisa e Ensino — Votuporanga,
- Foothills Hospital — Calgary, Alberta
- Western University & London Health Sciences Centre — London, Ontario
- Hopital du Sacre-Coeur de Montreal — Montreal, Quebec
- Nemocnice Ceske Budejovice a s — České Budějovice,
- Hepato-gastroenterologie HK, s.r.o. — Hradec Králové,
- ISCARE a.s. — Prague,
- CHU Amiens Picardie — Amiens,
- CHU de Clermont Ferrand — Clermont-Ferrand,
- CHRU de Lille Hopital Claude Huriez — Lille,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Crohn's Disease
- A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD) — Birmingham, Alabama
- A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease — Birmingham, Alabama
- A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease. — Sun City, Arizona
- Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice. — Blacktown, New South Wales
- Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis — Boston, Massachusetts
Explore by condition: All Crohn's Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.