A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis (NCT05242484)
A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.
Who can join: Review the eligibility criteria below.
Location: Valley Gastroenterology Medical Group — Arcadia, California
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (403 Sites)
Showing the first 25 of 403 sites.
- Valley Gastroenterology Medical Group — Arcadia, California
- Southern California Research Center — Coronado, California
- Om Research LLC — Lancaster, California
- Cedars Sinai Medical Center — Los Angeles, California
- University of California San Francisco — San Francisco, California
- University of Colorado — Aurora, Colorado
- Peak Gastroenterology Associates — Colorado Springs, Colorado
- Medical Research Center of Connecticut — Hamden, Connecticut
- Yale University — New Haven, Connecticut
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia
- Pioneer Research Solutions Inc. — Coconut Creek, Florida
- Digestive and Liver Disease Institute — Kissimmee, Florida
- Osceola Regional Hospital — Kissimmee, Florida
- Florida Research Center Inc. — Lakewood Rch, Florida
- University of Miami — Miami, Florida
- Gastroenterology Group Of Naples — Naples, Florida
- Omega Research Consultants — Orlando, Florida
- Synergy Clinical Research — St. Petersburg, Florida
- GCP Clinical Research — Tampa, Florida
- Atlanta Gastroenterology Associates — Atlanta, Georgia
- Gastroenterolgy Associates of Central GA — Macon, Georgia
- Atlanta Gastroenterology Associates 1 — Marietta, Georgia
- Gastrointestinal Specialists of Georgia — Marietta, Georgia
- Gastroenterology Consultants — Roswell, Georgia
- Grand Teton Gastroenterology — Idaho Falls, Idaho
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Colitis, Ulcerative
- A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis — Oakland, California
- A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis — Litchfield Park, Arizona
- Determination of the Optimal Treatment Target in Ulcerative Colitis — Ypsilanti, Michigan
- A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis — Kelowna, British Columbia
- A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis — San Francisco, California
Explore by condition: All Colitis, Ulcerative clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.