🏛️ Verified NIH Record • Updated 2026-08-27
A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (NCT05528510)
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab Subcutaneous Induction Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy, including clinical remission of guselkumab subcutaneous (SC) induction compared to placebo in participants with moderately to severely active ulcerative colitis (UC).
Who can join: Review the eligibility criteria below.
Location: Research Solutions of Arizona — Litchfield Park, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (236 Sites)
Showing the first 25 of 236 sites.
- Research Solutions of Arizona — Litchfield Park, Arizona
- Om Research LLC 1 — Apple Valley, California
- Om Research LLC — Lancaster, California
- Medical Associates Research Group, Inc. — San Diego, California
- Peak Gastroenterology Associates — Colorado Springs, Colorado
- Gastro Florida — Clearwater, Florida
- I.H.S. Health. LLC — Kissimmee, Florida
- Columbus Clinical Services LLC — Miami, Florida
- Vista Health Research, LLC — Miami, Florida
- Orlando Health — Orlando, Florida
- Theia Clincial Research, LLC — Temple Terrace, Florida
- Digestive Healthcare of Georgia, P.C — Atlanta, Georgia
- Atlanta Gastroenterology Associates — Atlanta, Georgia
- Gastroenterology Associates of Central GA — Macon, Georgia
- Cotton O'Neil Digestive Health Center — Topeka, Kansas
- Clinical Research Institute of Michigan, LLC — Chesterfield, Michigan
- Detroit Clinical Research Center — Farmington Hills, Michigan
- Smart Medical Research — Hollis, New York
- University of North Carolina — Chapel Hill, North Carolina
- Peters Medical Research — High Point, North Carolina
- Dayton Gastroenterology, Inc — Dayton, Ohio
- Gastro Intestinal Research Institute of Northern Ohio LLC — Westlake, Ohio
- Allegheny General Hospital of Research — Pittsburgh, Pennsylvania
- Frontier Clinical Research — Uniontown, Pennsylvania
- Gastroenterology Associates of Orangeburg, SC — Orangeburg, South Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Colitis, Ulcerative
- A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis — Oakland, California
- A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis — Arcadia, California
- Determination of the Optimal Treatment Target in Ulcerative Colitis — Ypsilanti, Michigan
- A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis — Kelowna, British Columbia
- A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis — San Francisco, California
Explore by condition: All Colitis, Ulcerative clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.