๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-13

Descemet Endothelial Thickness Comparison Trial II (NCT05275972)

Descemet Endothelial Thickness Comparison Trials (DETECT I & II)

๐ŸŸข Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Stanford University

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping Only (DSO) with adjunctive Ripasudil.

Who can join: Review the eligibility criteria below.

Location: Stanford University โ€” Palo Alto, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (8 Sites)

  • Stanford University โ€” Palo Alto, California
  • University of California Davis โ€” Sacramento, California
  • University of Miami โ€” Palm Beach Gardens, Florida
  • Dartmouth-Hitchcock Medical Center โ€” Lebanon, New Hampshire
  • Legacy Devers Eye Institute โ€” Portland, Oregon
  • Oregon Health & Science University โ€” Portland, Oregon
  • University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • Wills Eye Hospital โ€” Philadelphia, Pennsylvania

๐Ÿ“ž Contact the Study Coordinator

Phone: (650) 725-1688

Email: nvarnado@stanford.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Fuchs

Explore by condition: All Fuchs clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—