πŸ›οΈ Verified NIH Record β€’ Updated 2026-02-23

Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (NCT05280470)

A Phase 2, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody Drug Conjugate (ADC), in Subjects With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) (IDeate-Lung01)

πŸ”΅ Active, Not Recruiting Phase2 πŸ’Š Investigational Drug / Biologic Sponsor: Daiichi Sankyo

🩺 Plain-English Summary (8th-Grade Level)

This 2-part study intends to define the recommended Phase 2 dose of ifinatamab deruxtecan (I-DXd) based on the efficacy, safety, and pharmacokinetics (PK) results observed in participants with Extensive-stage Small Cell Lung Cancer (ES-SCLC) who received at least 1 prior line of platinum-based chemotherapy and a maximum of 3 prior lines of therapy (Part 1) and a minimum of two previous lines of systemic therapy (Part 2). This study will also investigate I-DXd anti-tumor activity in this population.

Who can join: Review the eligibility criteria below.

Location: Highlands Oncology Group β€” Springdale, Arkansas

Age range: 18 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (58 Sites)

Showing the first 25 of 58 sites.

  • Highlands Oncology Group β€” Springdale, Arkansas
  • The Cancer Specialists, Llc β€” Jacksonville, Florida
  • H. Lee Moffitt Cancer Center and Research Institute β€” Tampa, Florida
  • University of Chicago Medical Center β€” Chicago, Illinois
  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center β€” Baltimore, Maryland
  • Dana-Faeber Cancer Institute β€” Boston, Massachusetts
  • Henry Ford Hospital β€” Detroit, Michigan
  • Cancer and Hematology Centers of Western Michigan β€” Grand Rapids, Michigan
  • Washington University School of Medicine β€” St Louis, Missouri
  • Hackensack Meridian Health-Southern Ocean Medical Center β€” Manahawkin, New Jersey
  • Memorial Sloan-Kettering Cancer Center (Mskcc) - New York β€” New York, New York
  • Montefiore Medical Center Prime β€” The Bronx, New York
  • Duke University Health System β€” Durham, North Carolina
  • Sarah Cannon (Tennessee Oncology - Nashville) β€” Nashville, Tennessee
  • Millennium Physicians Association, Llp β€” Houston, Texas
  • University of Washington Medical Center β€” Seattle, Washington
  • Jilin Cancer Hospital β€” Changchun,
  • Hunan Cancer Hospital β€” Changsha,
  • West China Hospital, Sichuan University β€” Chengdu,
  • Guangdong Provincial People'S Hospital β€” Guangdong,
  • Zhejiang Cancer Hospital β€” Hangzhou,
  • Linyi Cancer Hospital β€” Linyi,
  • Fudan University Shanghai Cancer Center β€” Shanghai,
  • Union Hospital of Tongji Medical College Huazhong University of Science and Technology β€” Wuhan,
  • Centre Hospitalier Intercommunal de CrΓ©teil β€” CrΓ©teil,

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—