Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (NCT05280470)
A Phase 2, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody Drug Conjugate (ADC), in Subjects With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) (IDeate-Lung01)
π©Ί Plain-English Summary (8th-Grade Level)
This 2-part study intends to define the recommended Phase 2 dose of ifinatamab deruxtecan (I-DXd) based on the efficacy, safety, and pharmacokinetics (PK) results observed in participants with Extensive-stage Small Cell Lung Cancer (ES-SCLC) who received at least 1 prior line of platinum-based chemotherapy and a maximum of 3 prior lines of therapy (Part 1) and a minimum of two previous lines of systemic therapy (Part 2). This study will also investigate I-DXd anti-tumor activity in this population.
Who can join: Review the eligibility criteria below.
Location: Highlands Oncology Group β Springdale, Arkansas
Age range: 18 Years
π§ͺ Interventions in This Study
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (58 Sites)
Showing the first 25 of 58 sites.
- Highlands Oncology Group β Springdale, Arkansas
- The Cancer Specialists, Llc β Jacksonville, Florida
- H. Lee Moffitt Cancer Center and Research Institute β Tampa, Florida
- University of Chicago Medical Center β Chicago, Illinois
- Johns Hopkins Sidney Kimmel Comprehensive Cancer Center β Baltimore, Maryland
- Dana-Faeber Cancer Institute β Boston, Massachusetts
- Henry Ford Hospital β Detroit, Michigan
- Cancer and Hematology Centers of Western Michigan β Grand Rapids, Michigan
- Washington University School of Medicine β St Louis, Missouri
- Hackensack Meridian Health-Southern Ocean Medical Center β Manahawkin, New Jersey
- Memorial Sloan-Kettering Cancer Center (Mskcc) - New York β New York, New York
- Montefiore Medical Center Prime β The Bronx, New York
- Duke University Health System β Durham, North Carolina
- Sarah Cannon (Tennessee Oncology - Nashville) β Nashville, Tennessee
- Millennium Physicians Association, Llp β Houston, Texas
- University of Washington Medical Center β Seattle, Washington
- Jilin Cancer Hospital β Changchun,
- Hunan Cancer Hospital β Changsha,
- West China Hospital, Sichuan University β Chengdu,
- Guangdong Provincial People'S Hospital β Guangdong,
- Zhejiang Cancer Hospital β Hangzhou,
- Linyi Cancer Hospital β Linyi,
- Fudan University Shanghai Cancer Center β Shanghai,
- Union Hospital of Tongji Medical College Huazhong University of Science and Technology β Wuhan,
- Centre Hospitalier Intercommunal de CrΓ©teil β CrΓ©teil,
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Extensive-stage Small-cell Lung Cancer
- Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab β Mobile, Alabama
- Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy β Anchorage, Alaska
- MGC018 in Patients With Relapsed or Refractory Extensive-Stage Small-Cell Lung Cancer β Washington D.C., District of Columbia
- A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC β Los Angeles, California
- Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer β Tucson, Arizona
Explore by condition: All Extensive-stage Small-cell Lung Cancer clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.