Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer (NCT06712355)
A Phase III, Multisite, Double-blinded Randomized Trial of BNT327 in Combination With Chemotherapy (Etoposide/Carboplatin) Compared to Atezolizumab in Combination With Chemotherapy (Etoposide/Carboplatin) in Participants With First-line Extensive-stage Small-cell Lung Cancer
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).
Who can join: Review the eligibility criteria below.
Location: ACRC Arizona Clinical Research Center โ Tucson, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (221 Sites)
Showing the first 25 of 221 sites.
- ACRC Arizona Clinical Research Center โ Tucson, Arizona
- Clermont Oncology Center โ Clermont, Florida
- Cancer Care Centers of Brevard, Inc โ Palm Bay, Florida
- Northside Hospital Atlanta โ Atlanta, Georgia
- Illinois Cancer Specialists โ Niles, Illinois
- Fort Wayne Medical Oncology and Hematology, Inc โ Fort Wayne, Indiana
- McFarland Clinic โ Ames, Iowa
- Helen G. Nassif Community Cancer Center โ Cedar Rapids, Iowa
- Baptist Health Hardin Cancer Center โ Elizabethtown, Kentucky
- LSU Health Baton Rouge - North Clinic โ Baton Rouge, Louisiana
- Our Lady of the Lake Hospital, Inc. โ Baton Rouge, Louisiana
- Frederick Health Hospital- James M Stockman Cancer Institute โ Frederick, Maryland
- Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center โ Burlington, Massachusetts
- Baptist Cancer Center โ Southaven, Mississippi
- Washington University School of Medicine โ St Louis, Missouri
- Nebraska Hematology-Oncology (NHO) โ Lincoln, Nebraska
- Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center โ New York, New York
- White Plains Hospital โ White Plains, New York
- Cleveland Clinic - Akron General Hematology & Oncology โ Akron, Ohio
- Cleveland Clinic Mercy Hospital Cancer Center โ Canton, Ohio
- The Christ Hospital Cancer Center โ Cincinnati, Ohio
- University Hospitals Cleveland Medical Center โ Cleveland, Ohio
- The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion โ Cleveland, Ohio
- Cleveland Clinic Foundation โ Cleveland, Ohio
- Kettering Medical Center โ Kettering, Ohio
๐ Contact the Study Coordinator
Phone: (496) 131-9084
Email: patients@biontech.de
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Extensive-stage Small-cell Lung Cancer
- Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC) โ Springdale, Arkansas
- Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab โ Mobile, Alabama
- Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy โ Anchorage, Alaska
- MGC018 in Patients With Relapsed or Refractory Extensive-Stage Small-Cell Lung Cancer โ Washington D.C., District of Columbia
- A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC โ Los Angeles, California
Explore by condition: All Extensive-stage Small-cell Lung Cancer clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.