๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-23

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer (NCT06712355)

A Phase III, Multisite, Double-blinded Randomized Trial of BNT327 in Combination With Chemotherapy (Etoposide/Carboplatin) Compared to Atezolizumab in Combination With Chemotherapy (Etoposide/Carboplatin) in Participants With First-line Extensive-stage Small-cell Lung Cancer

๐ŸŸข Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: BioNTech SE

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).

Who can join: Review the eligibility criteria below.

Location: ACRC Arizona Clinical Research Center โ€” Tucson, Arizona

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (221 Sites)

Showing the first 25 of 221 sites.

  • ACRC Arizona Clinical Research Center โ€” Tucson, Arizona
  • Clermont Oncology Center โ€” Clermont, Florida
  • Cancer Care Centers of Brevard, Inc โ€” Palm Bay, Florida
  • Northside Hospital Atlanta โ€” Atlanta, Georgia
  • Illinois Cancer Specialists โ€” Niles, Illinois
  • Fort Wayne Medical Oncology and Hematology, Inc โ€” Fort Wayne, Indiana
  • McFarland Clinic โ€” Ames, Iowa
  • Helen G. Nassif Community Cancer Center โ€” Cedar Rapids, Iowa
  • Baptist Health Hardin Cancer Center โ€” Elizabethtown, Kentucky
  • LSU Health Baton Rouge - North Clinic โ€” Baton Rouge, Louisiana
  • Our Lady of the Lake Hospital, Inc. โ€” Baton Rouge, Louisiana
  • Frederick Health Hospital- James M Stockman Cancer Institute โ€” Frederick, Maryland
  • Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center โ€” Burlington, Massachusetts
  • Baptist Cancer Center โ€” Southaven, Mississippi
  • Washington University School of Medicine โ€” St Louis, Missouri
  • Nebraska Hematology-Oncology (NHO) โ€” Lincoln, Nebraska
  • Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center โ€” New York, New York
  • White Plains Hospital โ€” White Plains, New York
  • Cleveland Clinic - Akron General Hematology & Oncology โ€” Akron, Ohio
  • Cleveland Clinic Mercy Hospital Cancer Center โ€” Canton, Ohio
  • The Christ Hospital Cancer Center โ€” Cincinnati, Ohio
  • University Hospitals Cleveland Medical Center โ€” Cleveland, Ohio
  • The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion โ€” Cleveland, Ohio
  • Cleveland Clinic Foundation โ€” Cleveland, Ohio
  • Kettering Medical Center โ€” Kettering, Ohio

๐Ÿ“ž Contact the Study Coordinator

Phone: (496) 131-9084

Email: patients@biontech.de

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—