🏛️ Verified NIH Record • Updated 2026-07-10

Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC (NCT05301842)

A Phase III, Randomized, Open-Label, Sponsor-Blinded, Multicenter Study of Durvalumab in Combination With Tremelimumab ± Lenvatinib Given Concurrently With TACE Compared to TACE Alone in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-3)

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab, tremelimumab and lenvatinib therapy in patients with locoregional hepatocellular carcinoma

Who can join: Review the eligibility criteria below.

Location: Research Site — Birmingham, Alabama

Age range: 18 Years to 120 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (171 Sites)

Showing the first 25 of 171 sites.

  • Research Site — Birmingham, Alabama
  • Research Site — Mobile, Alabama
  • Research Site — Yuma, Arizona
  • Research Site — Glendale, California
  • Research Site — Atlanta, Georgia
  • Research Site — Baltimore, Maryland
  • Research Site — Santa Fe, New Mexico
  • Research Site — Commack, New York
  • Research Site — New York, New York
  • Research Site — Memphis, Tennessee
  • Research Site — Dallas, Texas
  • Research Site — Houston, Texas
  • Research Site — Brussels,
  • Research Site — Ghent,
  • Research Site — Barretos,
  • Research Site — Brasília,
  • Research Site — Niterói,
  • Research Site — Porto Alegre,
  • Research Site — Rio de Janeiro,
  • Research Site — Santa Maria,
  • Research Site — Santo André,
  • Research Site — São Paulo,
  • Research Site — Vitória,
  • Research Site — Calgary, Alberta
  • Research Site — Halifax, Nova Scotia

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗