Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events (NCT05360446)
A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Phase IIIb Study Evaluating the Effect of Inclisiran on Atherosclerotic Plaque Progression Assessed by Coronary Computed Tomography Angiography (CCTA) in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events (VICTORION-PLAQUE)
🩺 Plain-English Summary (8th-Grade Level)
CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's vessels as measured by coronary computed tomography angiography (CCTA) from baseline to month 24. This study is being conducted in eligible participants with a diagnosis of non-obstructive coronary artery disease (NOCAD), where the coronary arteries are blocked less than 50%, and with no previous cardiovascular events.
Who can join: Review the eligibility criteria below.
Location: Heart Center Research Llc — Huntsville, Alabama
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (89 Sites)
Showing the first 25 of 89 sites.
- Heart Center Research Llc — Huntsville, Alabama
- Alaska Heart and Vascular — Anchorage, Alaska
- Cardiovascular Res Found — Beverly Hills, California
- UC San Diego Health — La Jolla, California
- Stanford Health Care — Stanford, California
- Lundquist Inst BioMed at Harbor — Torrance, California
- Bridgeport Hospital — Bridgeport, Connecticut
- George Washington Univ Medical Ctr — Washington D.C., District of Columbia
- Inpatient Research Clinical LLC — Miami Lakes, Florida
- NorthShore University Health System — Evanston, Illinois
- Reid Physician Associates — Richmond, Indiana
- Midwest Heart and Vascular Spec — Overland Park, Kansas
- Anderson Medical Research — Ft. Washington, Maryland
- Minneapolis Heart Institute — Minneapolis, Minnesota
- R Ins For Heart And Vascular Health — Reno, Nevada
- Cardio Metabolic Institute — Somerset, New Jersey
- Icahn School of Med at Mt Sinai — New York, New York
- State Uni of NY at Stony Brook — Stony Brook, New York
- Westchester Medical Center — Valhalla, New York
- Aultman Hospital — Canton, Ohio
- Oregon Health Sciences University — Portland, Oregon
- Soltero Cardiovascular Research Center — Dallas, Texas
- Orion Medical — Houston, Texas
- Inova Fairfax Hospital — Falls Church, Virginia
- Virginia Heart — Falls Church, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD — Mobile, Alabama
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Explore by condition: All Coronary Artery Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.