Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01) (NCT05464030)
A Phase I, Multicenter, Open-Label First in Human Study of Anti-CEACAM5 Antibody Drug Conjugate M9140 in Participants With Advanced Solid Tumors (PROCEADE-CRC-01)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this first in-human study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary clinical activity of M9140 in advanced solid tumors. This study contains 2 parts: Dose escalation (Part 1) and dose expansion (Part 2) Study details include: * Study Duration per participant: Approximately 4 months for Part 1 and 8 months for Part 2 * M9140 is not available through an expanded access program
Who can join: Review the eligibility criteria below.
Location: California Cancer Associates for Research & Excellence, Inc. — Encinitas, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (35 Sites)
Showing the first 25 of 35 sites.
- California Cancer Associates for Research & Excellence, Inc. — Encinitas, California
- California Cancer Associates for Research & Excellence, Inc. — Fresno, California
- Rhode Island Hospital — Providence, Rhode Island
- Mary Crowley Cancer Research — Dallas, Texas
- MD Anderson Cancer Center - Oncology — Houston, Texas
- NEXT Oncology — San Antonio, Texas
- The Ottawa Hospital Cancer Centre — Ottawa,
- University Health Network - Princess Margaret Cancer Centre — Toronto,
- National Cancer Center Hospital - Dept of Gastroenterology — Chūōku,
- National Cancer Center Hospital East — Kashiwa-shi,
- Saitama Cancer Center — Kitaadachi-gun,
- Cancer Institute Hospital of JFCR — Kōtoku,
- Aichi Cancer Center Hospital — Nagoya,
- Kindai University Hospital — Osakasayama-shi,
- Shizuoka Cancer Center — Sunto-gun,
- Kanagawa Cancer Center — Yokohama,
- Kyungpook National University Chilgok Hospital — Daegu,
- National Cancer Center — Goyang-si,
- Seoul National University Bundang Hospital — Seongnam,
- Asan Medical Center — Seoul,
- Samsung Medical Center — Seoul,
- Seoul National University Hospital — Seoul,
- Severance Hospital, Yonsei University Health System — Seoul,
- Hospital Clinic de Barcelona — Barcelona,
- Hospital del Mar — Barcelona,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.