🏛️ Verified NIH Record • Updated 2026-03-20
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial (NCT05478304)
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: AtriCure, Inc.
🩺 Plain-English Summary (8th-Grade Level)
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke.
Who can join: Review the eligibility criteria below.
Location: Heart Center Research / Huntsville Hospital — Huntsville, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (138 Sites)
Showing the first 25 of 138 sites.
- Heart Center Research / Huntsville Hospital — Huntsville, Alabama
- HonorHealth Shea Scottsdale Healthcare — Scottsdale, Arizona
- St. Bernard's Heart & Vascular — Jonesboro, Arkansas
- CHI St. Vincent — Little Rock, Arkansas
- Arkansas Heart Hospital — Little Rock, Arkansas
- Memorial Care Long Beach Medical Center — Long Beach, California
- Keck Medical Center of USC — Los Angeles, California
- Hoag Memorial Hospital Presbyterian — Newport Beach, California
- Sutter Sacramento Hospital — Sacramento, California
- Stanford University — Stanford, California
- University of Colorado — Boulder, Colorado
- Hartford Hospital — Hartford, Connecticut
- Christiana Care Health Services — Newark, Delaware
- Medstar Washington Hospital Center — Washington D.C., District of Columbia
- HCA Florida JFK Hospital — Atlantis, Florida
- HealthPark Medical Center — Fort Myers, Florida
- University of Florida Hospital — Gainesville, Florida
- Memorial Regional Hospital — Hollywood, Florida
- Baptist Health Jacksonville — Jacksonville, Florida
- Baptist Health South Florida — Miami, Florida
- Orlando Regional Medical Center — Orlando, Florida
- Sarasota Memorial Hospital — Sarasota, Florida
- Tampa General Hospital — Tampa, Florida
- Baycare Health System — Tampa, Florida
- Emory University Hospital — Atlanta, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Ischemic Stroke clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.