Adipose Dysfunction, Imaging, Physiology, and Outcomes With Sodium Glucose Cotransporter 2 Inhibitor (SGLT2i) for Sleep Apnea: The ADIPOSA Study (NCT05612594)
Adipose Dysfunction, Imaging, Physiology, and Outcomes With SGLT2i's for Sleep Apnea: The ADIPOSA Study
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to test if bexagliflozin lowers the sleep apnea severity in adults who are overweight or obese with moderate to severe obstructive sleep apnea (OSA) compared with a placebo (look-alike substance that contains no active drug). The main question it aims to answer is: * If SGLT2i will reduce anatomic and physiologic traits, clinical measures of OSA and sleep deficiency in participants * If improvement in clinical measures are because of improvement in the anatomic and physiologic traits. Participants will be placed on either drug or placebo and get routine normal care for 6 months. At the start and end of the study, participants will undergo different clinical measurements to see if the drug makes the sleep apnea better.
Who can join: Review the eligibility criteria below.
Location: Yale New Haven Health — New Haven, Connecticut
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Yale New Haven Health — New Haven, Connecticut
- University Hospitals Cleveland Medical Center — Cleveland, Ohio
📞 Contact the Study Coordinator
Phone: (203) 785-4163
Email: henry.yaggi@yale.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Sleep Apnea
- Mechanisms of Prediabetic States in Sleep Apnea — Chicago, Illinois
- Technology-Supported Treatment of Sleep Apnea in Prediabetes — Chicago, Illinois
- Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea — La Jolla, California
- Behavioral Optimization to Overcome Obstructive Sleep Apnea Treatment Barriers — West Los Angeles, California
- Janus II Feasibility — Scottsdale, Arizona
- Sleep Disordered Breathing With Opioid Use — Detroit, Michigan
Explore by condition: All Sleep Apnea clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.