Pathological Myeloid Activation After Sepsis and Trauma (NCT05616130)
Pathological Myeloid Activation After Sepsis and Trauma Subtitle: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
🩺 Plain-English Summary (8th-Grade Level)
The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury. The main questions it aims to answer are: Is severe human trauma associated with specific patterns of development in the hematopoietic stem cells of these patients? and Does the initial severe trauma injury create immunosuppression and increase risk of in-hospital sepsis? Participants in study will give blood samples and a waste sample of bone marrow at time of operative repair of traumatic orthopedic injuries, supply medical information and participate in surveys and assessments during recovery from their injury(ies). Researchers will compare severe trauma injury patients to elective hip repair patients to see if immunosuppression and specific development patterns occur in the trauma patient versus the otherwise healthy hip surgery patient.
Who can join: Review the eligibility criteria below.
Location: UF Health at Shands Hospital — Gainesville, Florida
Age range: 18 Years to 100 Years
🧪 Interventions in This Study
- Data Collection (OTHER)
- Bone marrow collection and blood collection (PROCEDURE)
- Serial interviews to complete surveys and questionnaires (OTHER)
- Telephone follow up call (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UF Health at Shands Hospital — Gainesville, Florida
📞 Contact the Study Coordinator
Phone: (352) 273-8759
Email: ruth.davis@surgery.ufl.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Trauma Injury
- Reducing Low-value Care for Trauma Admissions — Québec, Quebec
- OCT in Open Fracture and Infected Fracture — Lebanon, New Hampshire
- Bioimpedance for Ortho Trauma — Lebanon, New Hampshire
- The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma — Gainesville, Florida
- Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries — Boston, Massachusetts
- Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury — Gainesville, Florida
Explore by condition: All Trauma Injury clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.