A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (HOPE Study) (NCT05637801)
A Randomized, Double-blind, Sham-controlled Pivotal Study of Sensory Stimulation in Subjects With Alzheimer's Disease (HOPE Study)
🩺 Plain-English Summary (8th-Grade Level)
This is a randomized, double-blind, sham-controlled pivotal study of sensory stimulation in subjects with mild to moderate AD. Up to approximately 670 subjects will be treated with either Active or Sham investigational device, Spectris™ AD, for 60 minutes daily for approximately 12 months. Efficacy will be measured using the Integrated Alzheimer's Disease Mini-Mental State Exam (MMSE) Activities of Daily Living (ADCS-ADL) Rating Scale (iADMARS).
Who can join: Review the eligibility criteria below.
Location: CCT Research - Gilbert Neurology Partners — Gilbert, Arizona
Age range: 50 Years to 90 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (68 Sites)
Showing the first 25 of 68 sites.
- CCT Research - Gilbert Neurology Partners — Gilbert, Arizona
- Barrow Neurological Institute — Phoenix, Arizona
- CCT Research - Foothills Research Center — Phoenix, Arizona
- Banner Sun Health Research Institute — Sun City, Arizona
- Advanced Research Center, Inc — Anaheim, California
- ATP Clinical Research, Inc. — Costa Mesa, California
- Neurology Center of North Orange County — Fullerton, California
- Syrentis Clinical Research — Santa Ana, California
- Office of Elizabeth Zarate-Rowell, MD — Seal Beach, California
- Mile High Research Center — Denver, Colorado
- JEM Research Institute — Atlantis, Florida
- Visionary Investigators Network- Aventura — Aventura, Florida
- South Lake Pain Institute — Clermont, Florida
- Arrow Clinical Trials — Daytona Beach, Florida
- Brain Matters Research — Delray Beach, Florida
- Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida
- Alphab Global Research — Jupiter, Florida
- Charter Research - Lady Lake — Lady Lake, Florida
- Multi-Specialty Research Associates, Inc. — Lake City, Florida
- Premier Clinical Research Institute Inc. — Miami, Florida
- Visionary Investigators Network- Miami — Miami, Florida
- Aqualane Clinical Research — Naples, Florida
- Coastal Family Medicine - Orange Park — Orange Park, Florida
- K2 Medical Research - Orlando — Orlando, Florida
- Emerald Coast Neurology — Pensacola, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alzheimer Disease
- The Use of Memantine for Prevention of Alzheimer's Disease — Charlottesville, Virginia
- Investigation of Inflammation Using [C-11]-CS1P1 — St Louis, Missouri
- Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia — Palo Alto, California
- High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease — Cambridge, Massachusetts
- A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease — Phoenix, Arizona
Explore by condition: All Alzheimer Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.