🏛️ Verified NIH Record • Updated 2026-02-27
A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer (NCT05654623)
A PHASE 3, RANDOMIZED, OPEN-LABEL, MULTICENTER TRIAL OF ARV-471 (PF-07850327) VS FULVESTRANT IN PARTICIPANTS WITH ESTROGEN RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR ENDOCRINE BASED TREATMENT FOR ADVANCED DISEASE (VERITAC-2)
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Pfizer
🩺 Plain-English Summary (8th-Grade Level)
A study to learn about a new medicine called ARV-471 (PF-07850327) in people who have advanced metastatic breast cancer.
Who can join: Review the eligibility criteria below.
Location: California Cancer Associates for Research and Excellence, Inc. (cCARE) — Encinitas, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (312 Sites)
Showing the first 25 of 312 sites.
- California Cancer Associates for Research and Excellence, Inc. (cCARE) — Encinitas, California
- Orange Coast Memorial Medical Center — Fountain Valley, California
- California Cancer Associates for Research and Excellence — Fresno, California
- Providence Queen of the Valley Medical Center — Napa, California
- California Cancer Associates for Research and Excellence — San Marcos, California
- Olive View-UCLA Medical Center — Sylmar, California
- Smilow Cancer Hospital Care Center at Fairfield — Fairfield, Connecticut
- Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut
- Yale-New Haven Hospital — New Haven, Connecticut
- Smilow Cancer Hospital Care Center at North Haven — North Haven, Connecticut
- Smilow Cancer Hospital Care Center at Trumbull — Trumbull, Connecticut
- Florida Cancer Specialists — Altamonte Springs, Florida
- Florida Cancer Specialists BON — Bonita Springs, Florida
- Florida Cancer Specialists BCC — Bradenton, Florida
- Florida Cancer Specialists LRS — Bradenton, Florida
- Florida Cancer Specialists — Brandon, Florida
- Florida Cancer Specialists NFM — Cape Coral, Florida
- Morton Plant Hospital - BayCare Health System — Clearwater, Florida
- Florida Cancer Specialists — Clearwater, Florida
- Florida Cancer Specialists — Daytona Beach, Florida
- Florida Cancer Specialists COL — Fort Myers, Florida
- Florida Cancer Specialists GLO — Fort Myers, Florida
- Florida Cancer Specialists — Gainesville, Florida
- Lakeland Regional Cancer Center — Lakeland, Florida
- Florida Cancer Specialists — Largo, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Breast Cancer
- RCT of CBD for Anxiety in Advanced Breast Cancer — Boston, Massachusetts
- A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer — Springdale, Arkansas
- Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer — St Louis, Missouri
- Engage Psychosocial Intervention for Cancer Symptoms — Durham, North Carolina
- A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors — Duarte, California
Explore by condition: All Advanced Breast Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.