๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-06

A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer (NCT06638307)

A Phase 1, First-in-Human Study of MEN2312, a KAT6 Inhibitor, as Monotherapy and in Combination in Participants With Advanced Breast Cancer

๐ŸŸข Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Stemline Therapeutics, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a first-in-human study of MEN2312, a lysine acetyltransferase 6 (KAT6) inhibitor, in adult participants with advanced breast cancer.

Who can join: Review the eligibility criteria below.

Location: Highlands Oncology Group โ€” Springdale, Arkansas

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (45 Sites)

Showing the first 25 of 45 sites.

  • Highlands Oncology Group โ€” Springdale, Arkansas
  • City of Hope โ€” Duarte, California
  • UC San Diego Moores Cancer Center โ€” La Jolla, California
  • Stanford Cancer Center โ€” Palo Alto, California
  • UCSF Helen Diller Family Comprehensive Cancer Center โ€” San Francisco, California
  • UCLA Hematology Oncology - Parkside โ€” Santa Monica, California
  • Yale Comprehensive Cancer Center โ€” New Haven, Connecticut
  • Advent Health Orlando โ€” Altamonte Springs, Florida
  • Sarah Cannon Research Institute at Florida Cancer Specialists โ€” Orlando, Florida
  • Florida Cancer Specialists & Research Institute (FCS) - Sarasota โ€” Sarasota, Florida
  • Moffitt Cancer Center โ€” Tampa, Florida
  • Winship Cancer Institute, Emory University โ€” Atlanta, Georgia
  • University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center) โ€” Chicago, Illinois
  • University of Chicago Medical Center โ€” Chicago, Illinois
  • University of Iowa Health Care โ€” Iowa City, Iowa
  • The University of Kansas Cancer Center โ€” Fairway, Kansas
  • Sidney Kimmel Comprehensive Cancer Center โ€” Baltimore, Maryland
  • Massachusetts General Hospital Cancer Center โ€” Boston, Massachusetts
  • Dana-Farber Cancer Institute โ€” Boston, Massachusetts
  • START Midwest - Oncology โ€” Grand Rapids, Michigan
  • Mayo Clinic โ€” Rochester, Minnesota
  • Astera Cancer Care โ€” East Brunswick, New Jersey
  • Perlmutter Cancer Center - Sunset Park โ€” Brooklyn, New York
  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island โ€” Mineola, New York
  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health โ€” New York, New York

๐Ÿ“ž Contact the Study Coordinator

Phone: (877) 332-7961

Email: clinicaltrials@menarinistemline.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—