REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels (NCT05669755)
The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease
🩺 Plain-English Summary (8th-Grade Level)
This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.
Who can join: Review the eligibility criteria below.
Location: Univ of Alabama Birmingham — Birmingham, Alabama
Age range: 55 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (633 Sites)
Showing the first 25 of 633 sites.
- Univ of Alabama Birmingham — Birmingham, Alabama
- Chambliss Clinical Trials LLC — Montgomery, Alabama
- Honor Health — Scottsdale, Arizona
- National Heart Institute Cal — Beverly Hills, California
- Valley Clinical Trials — Covina, California
- Scripps Wht Diab Inst La Jolla — La Jolla, California
- First Valley Medical Group — Lancaster, California
- Clinical Trials Research_Sacramento — Lincoln, California
- Torrance Clin Res Inst, Inc. — Lomita, California
- Pacific Clinical Studies — Los Alamitos, California
- Monterey Endocrine & Diabetes Institute, Inc — Monterey, California
- Valley Clinical Trials, Inc. — Northridge, California
- Desert Oasis Hlthcr Med Group — Palm Springs, California
- Western University of Health Sciences — Pomona, California
- Linda Vista Health Care Ctr — San Diego, California
- N America Res Inst - San Dimas — San Dimas, California
- Encompass Clinical Research_Spring Valley — Spring Valley, California
- Lundquist Inst.-Biom Inno-UCLA — Torrance, California
- Bridgeport Hospital — Bridgeport, Connecticut
- Innovative Research of W FL — Clearwater, Florida
- Florida Premier Cardiology — Delray Beach, Florida
- Fleming Island Center for Clinical Research — Fleming Island, Florida
- Life Spring Research Foundation LLC — Miami, Florida
- Oceane 7 Medical & Research Center, Inc. — Miami, Florida
- Reyes Clinical Research, Inc — Miami, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.