Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations (NCT05687266)
A Phase III, Randomised, Open-label, Multicentre, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Durvalumab and Carboplatin Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic NSCLC Without Actionable Genomic Alterations (D926NC00001; AVANZAR)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase III, randomized, open-label, multicenter, global study to compare the efficacy and safety of Datopotamab Deruxtecan (Dato-DXd) in combination with durvalumab and carboplatin compared with pembrolizumab in combination with histology-specific platinum-based chemotherapy as first-line treatment of adults with stage IIIB, IIIC, or IV NSCLC without actionable genomic alterations (including sensitizing EGFR mutations, and ALK and ROS1 rearrangements).
Who can join: Review the eligibility criteria below.
Location: Research Site — Phoenix, Arizona
Age range: 18 Years to 130 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (254 Sites)
Showing the first 25 of 254 sites.
- Research Site — Phoenix, Arizona
- Research Site — Tucson, Arizona
- Research Site — Hot Springs, Arkansas
- Research Site — Little Rock, Arkansas
- Research Site — Springdale, Arkansas
- Research Site — Fountain Valley, California
- Research Site — Los Angeles, California
- Research Site — Orange, California
- Research Site — Boulder, Colorado
- Research Site — Fort Myers, Florida
- Research Site — Jacksonville, Florida
- Research Site — St. Petersburg, Florida
- Research Site — West Palm Beach, Florida
- Research Site — Hinsdale, Illinois
- Research Site — Fort Wayne, Indiana
- Research Site — Bettendorf, Iowa
- Research Site — Iowa City, Iowa
- Research Site — Waukee, Iowa
- Research Site — Baton Rouge, Louisiana
- Research Site — Covington, Louisiana
- Research Site — Duluth, Minnesota
- Research Site — Rochester, Minnesota
- Research Site — Hannibal, Missouri
- Research Site — Lincoln, Nebraska
- Research Site — Lincoln, Nebraska
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.