Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy (NCT05703269)
Hypofractionated Radiotherapy vs Single Fraction Radiosurgery for Brain Metastasis Patients on Immunotherapy (HYPOGRYPHE)
🩺 Plain-English Summary (8th-Grade Level)
This study is designed to see if we can lower the chance of side effects from radiation in patients with breast, kidney, small cell lung cancer, non-small cell lung cancer or melanoma that has spread to the brain and who are also being treated with immunotherapy, specifically immune checkpoint inhibitor (ICI) therapy. This study will compare the usual care treatment of single fraction stereotactic radiosurgery (SSRS) given on one day versus fractionated stereotactic radiosurgery (FSRS), which is a lower dose of radiation given over a few days to determine if FSRS is better or worse at reducing side effects than usual care treatment.
Who can join: Review the eligibility criteria below.
Location: Lewis Cancer and Research Pavilion at Saint Joseph's/Candler — Savannah, Georgia
Age range: 18 Years
🧪 Interventions in This Study
- single fraction stereotactic radiosurgery (SSRS) (RADIATION)
- fractionated stereotactic radiosurgery (FSRS) (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (34 Sites)
Showing the first 25 of 34 sites.
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler — Savannah, Georgia
- Decatur Memorial Hospital — Decatur, Illinois
- Crossroads Cancer Center — Effingham, Illinois
- HSHS Saint Elizabeth's Hospital — O'Fallon, Illinois
- OSF Saint Francis Medical Center — Peoria, Illinois
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor — Ann Arbor, Michigan
- Trinity Health IHA Medical Group Hematology Oncology - Brighton — Brighton, Michigan
- Genesys Hurley Cancer Institute — Flint, Michigan
- Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus — Ypsilanti, Michigan
- Mercy Hospital Springfield — Springfield, Missouri
- Mercy Hospital South — St Louis, Missouri
- Lovelace Medical Center-Saint Joseph Square — Albuquerque, New Mexico
- Lovelace Radiation Oncology — Albuquerque, New Mexico
- Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina
- Atrium Health Cabarrus/LCI-Concord — Concord, North Carolina
- Wake Forest University Health Sciences — Winston-Salem, North Carolina
- Sanford Broadway Medical Center — Fargo, North Dakota
- Sanford Roger Maris Cancer Center — Fargo, North Dakota
- Mercy Health - Perrysburg Hospital — Perrysburg, Ohio
- Saint Joseph's/Candler - Bluffton Campus — Bluffton, South Carolina
- Saint Francis Hospital — Greenville, South Carolina
- Prisma Health Cancer Institute - Faris — Greenville, South Carolina
- Saint Francis Cancer Center — Greenville, South Carolina
- Gibbs Cancer Center-Pelham — Greer, South Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.