🏛️ Verified NIH Record • Updated 2026-08-06

A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms (NCT05936359)

A Phase 1, Open-Label, Multicenter Study of INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Incyte Corporation

🩺 Plain-English Summary (8th-Grade Level)

This study is being conducted to evaluate the safety, tolerability, and dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA033989 administered as a monotherapy or in combination with ruxolitinib in participants with myeloproliferative neoplasms.

Who can join: Review the eligibility criteria below.

Location: Royal Brisbane and Women'S Hospital — Herston, Queensland

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (28 Sites)

Showing the first 25 of 28 sites.

  • Royal Brisbane and Women'S Hospital — Herston, Queensland
  • Royal Adelaide Hospital — Adelaide, South Australia
  • Peter Maccallum Cancer Centre — Melbourne, Victoria
  • The Alfred Hospital — Melbourne, Victoria
  • Princess Margaret Cancer Center — Toronto, Ontario
  • Hopital Maisonneuve-Rosemont, Montreal, Qc — Montreal, Quebec
  • Sjaellands Universitetshospital — Roskilde,
  • Vejle Hospital — Vejle,
  • Institut Bergonie — Bordeaux,
  • Chu Nimes — Nîmes,
  • Hospital Saint Louis — Paris,
  • Institut Gustave Roussy — Villejuif,
  • University Medical Center Rwth Aachen — Aachen,
  • Universitatsklinikum Halle (Saale) — Halle,
  • Universitätsklinikum Ulm — Ulm,
  • Aou Policlinico S. Orsola-Malpighi — Bologna,
  • Azienda Ospedaliero-Universitaria Careggi (Aouc) — Florence,
  • Fondazione Irccs Ca Granda Ospedale Maggiore — Milan,
  • National Cancer Center Hospital East — Chiba-ken,
  • Kagoshima University Hospital — Kagoshima,
  • Osaka Metropolitan University Hospital — Osaka,
  • Nippon Medical School Hospital — Tokyo,
  • Mie University Hospital — Tsu,
  • Hospital Universitario 12 de Octubre — Madrid,
  • Hospital Universitari I Politecnic La Fe — Valencia,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗