A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms (NCT05936359)
A Phase 1, Open-Label, Multicenter Study of INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
🩺 Plain-English Summary (8th-Grade Level)
This study is being conducted to evaluate the safety, tolerability, and dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA033989 administered as a monotherapy or in combination with ruxolitinib in participants with myeloproliferative neoplasms.
Who can join: Review the eligibility criteria below.
Location: Royal Brisbane and Women'S Hospital — Herston, Queensland
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (28 Sites)
Showing the first 25 of 28 sites.
- Royal Brisbane and Women'S Hospital — Herston, Queensland
- Royal Adelaide Hospital — Adelaide, South Australia
- Peter Maccallum Cancer Centre — Melbourne, Victoria
- The Alfred Hospital — Melbourne, Victoria
- Princess Margaret Cancer Center — Toronto, Ontario
- Hopital Maisonneuve-Rosemont, Montreal, Qc — Montreal, Quebec
- Sjaellands Universitetshospital — Roskilde,
- Vejle Hospital — Vejle,
- Institut Bergonie — Bordeaux,
- Chu Nimes — Nîmes,
- Hospital Saint Louis — Paris,
- Institut Gustave Roussy — Villejuif,
- University Medical Center Rwth Aachen — Aachen,
- Universitatsklinikum Halle (Saale) — Halle,
- Universitätsklinikum Ulm — Ulm,
- Aou Policlinico S. Orsola-Malpighi — Bologna,
- Azienda Ospedaliero-Universitaria Careggi (Aouc) — Florence,
- Fondazione Irccs Ca Granda Ospedale Maggiore — Milan,
- National Cancer Center Hospital East — Chiba-ken,
- Kagoshima University Hospital — Kagoshima,
- Osaka Metropolitan University Hospital — Osaka,
- Nippon Medical School Hospital — Tokyo,
- Mie University Hospital — Tsu,
- Hospital Universitario 12 de Octubre — Madrid,
- Hospital Universitari I Politecnic La Fe — Valencia,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Myeloproliferative Neoplasms
- A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms — Birmingham, Alabama
- A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms — Duarte, California
- Study of INCA036978 in Participants With Myeloproliferative Neoplasms — Birmingham, Alabama
- Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation — Chicago, Illinois
- A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms — Phoenix, Arizona
Explore by condition: All Myeloproliferative Neoplasms clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.