Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors (NCT06005493)
A Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5863, a T Cell-engaging Bispecific Antibody That Targets Claudin 18.2 (CLDN18.2) and CD3 in Adult Participants With Advanced or Metastatic Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
This research is designed to determine if experimental treatment with AZD5863, a T cell-engaging bispecific antibody that targets Claudin 18.2 (CLDN18.2) and CD3, is safe, tolerable and has anti-cancer activity in patients with advanced solid tumors.
Who can join: Review the eligibility criteria below.
Location: Research Site — Jacksonville, Florida
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (25 Sites)
- Research Site — Jacksonville, Florida
- Research Site — Rochester, Minnesota
- Research Site — New York, New York
- Research Site — Beijing,
- Research Site — Beijing,
- Research Site — Shandong,
- Research Site — Toulouse,
- Research Site — Villejuif,
- Research Site — Chūōku,
- Research Site — Kashiwa,
- Research Site — Kōtoku,
- Research Site — Amsterdam,
- Research Site — Groningen,
- Research Site — Rotterdam,
- Research Site — Seoul,
- Research Site — Seoul,
- Research Site — Seoul,
- Research Site — Seoul,
- Research Site — Kaohsiung City,
- Research Site — Tainan,
- Research Site — Taoyuan,
- Research Site — Dundee,
- Research Site — London,
- Research Site — Metropolitan Borough of Wirral,
- Research Site — Oxford,
📞 Contact the Study Coordinator
Phone: (877) 240-9479
Email: information.center@astrazeneca.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.