🏛️ Verified NIH Record • Updated 2025-11-25

CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study (NCT06073574)

The CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Ionis Pharmaceuticals, Inc.

🩺 Plain-English Summary (8th-Grade Level)

The main purpose of this study is to measure the amyloid burden, defined as extracellular volume (ECV) assessed by Magnetic Resonance Imaging (MRI) over time in a subset of up to 150 participants enrolled in ION-682884-CS2 (NCT04136171).

Who can join: Review the eligibility criteria below.

Location: Brigham and Women's Hospital — Boston, Massachusetts

Age range: 18 Years to 90 Years

🧪 Interventions in This Study

  • Cardiac MRI (DIAGNOSTIC_TEST)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (11 Sites)

  • Brigham and Women's Hospital — Boston, Massachusetts
  • Oregon Health and Science University — Portland, Oregon
  • Azienda Ospedaliero - Universitaria Careggi — Florence,
  • Azienda Ospedale Università di Padova — Padova,
  • Hospital Universitario Puerta de Hierro — Majadahonda,
  • Synexus - Scotland Clinical Research Centre — Bellshill,
  • Synexus Midlands Clinical Research Centre — Birmingham,
  • Synexus - Wales — Cardiff,
  • Royal Free London NHS Foundation Trust — London,
  • Richmond Pharmacology — London,
  • Synexus - Manchester Clinical Research Centre — Manchester,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗