🏛️ Verified NIH Record • Updated 2025-11-25
The CARDIO-TTRansform Scintigraphy Sub-study (NCT06073587)
CARDIO-TTRansform ION-682884-CS2-Scintigraphy Sub-study
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Ionis Pharmaceuticals, Inc.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to examine the changes in amyloid myocardial burden in a subset of the population participating in the ION682884-CS2 (NCT04136171) study, up to 150 participants, after treatment with eplontersen or placebo based on scintigraphy scans performed at Week 140 using the Perugini grade score method.
Who can join: Review the eligibility criteria below.
Location: Columbia University Irving Medical Center — New York, New York
Age range: 18 Years to 90 Years
🧪 Interventions in This Study
- Scintigraphy scan (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- Columbia University Irving Medical Center — New York, New York
- Duke University Medical Center — Durham, North Carolina
- Cleveland Clinic Main Campus — Cleveland, Ohio
- Oregon Health and Science University — Portland, Oregon
- Hospital Universitario Puerta de Hierro — Majadahonda,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
- CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study — Boston, Massachusetts
Explore by condition: All Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.