๐๏ธ Verified NIH Record โข Updated 2026-08-18
A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma (NCT06084884)
A Phase I/II Open-Label Study to Evaluate the Safety, Cellular Kinetics and Efficacy of AZD5851, a Chimeric Antigen Receptor T-Cell (CAR-T) Therapy Directed Against GPC3 in Adult Participants With Advanced/Recurrent Hepatocellular Carcinoma: ATHENA
๐ต Active, Not Recruiting Phase1 / Phase2 ๐ Investigational Drug / Biologic Sponsor: AstraZeneca
๐ฉบ Plain-English Summary (8th-Grade Level)
A Phase I/II study to evaluate AZD5851 in patients with GPC3+ advanced/recurrent hepatocellular carcinoma.
Who can join: Review the eligibility criteria below.
Location: Research Site โ Phoenix, Arizona
Age range: 18 Years to 130 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (19 Sites)
- Research Site โ Phoenix, Arizona
- Research Site โ Duarte, California
- Research Site โ Los Angeles, California
- Research Site โ Orange, California
- Research Site โ San Francisco, California
- Research Site โ Washington D.C., District of Columbia
- Research Site โ Jacksonville, Florida
- Research Site โ Atlanta, Georgia
- Research Site โ Westwood, Kansas
- Research Site โ Rochester, Minnesota
- Research Site โ Hackensack, New Jersey
- Research Site โ New York, New York
- Research Site โ Columbus, Ohio
- Research Site โ Portland, Oregon
- Research Site โ Philadelphia, Pennsylvania
- Research Site โ Pittsburgh, Pennsylvania
- Research Site โ Kashiwa,
- Research Site โ Osakasayama-shi,
- Research Site โ Seoul,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Hepatocellular Carcinoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.