๐๏ธ Verified NIH Record โข Updated 2026-07-09
A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis (NCT06096779)
A Phase II, Open-label, Multi-cohort, Multicenter Study in Patients With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis
๐ต Active, Not Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Genentech, Inc.
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the safety of atezolizumab and bevacizumab, or atezolizumab alone, as first-line treatment in participants with unresectable, locally advanced or metastatic hepatocellular carcinoma (HCC) with Child-pugh B7 or B8 cirrhosis.
Who can join: Review the eligibility criteria below.
Location: University of Arizona Cancer Center โ Tucson, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (59 Sites)
Showing the first 25 of 59 sites.
- University of Arizona Cancer Center โ Tucson, Arizona
- UC San Diego Moores Cancer Center โ La Jolla, California
- University of Southern California-Keck School of Medicine -1975 Zonal Ave โ Los Angeles, California
- University of Southern California โ Newport Beach, California
- University of California Irvine Medical Center โ Orange, California
- California Liver Research Institute โ Pasadena, California
- University of California Davis Medical Center โ Sacramento, California
- Stanford Health Care โ Stanford, California
- Harbor UCLA Medical Center โ Torrance, California
- Cedars Sinai Comprehensive Transplant Center โ West Hollywood, California
- Rocky Mountain Cancer Centers (Williams) - USOR โ Denver, Colorado
- Hartford Healthcare Cancer Institute at Hartford Hospital โ Hartford, Connecticut
- George Washington University- Medical Faculty Associates โ Washington D.C., District of Columbia
- Washington DC VA Medical Center โ Washington D.C., District of Columbia
- Orlando Health Inc. โ Orlando, Florida
- Northwestern University โ Chicago, Illinois
- University of Illinois Health Outpatient Care Center โ Chicago, Illinois
- The Duchossois Center for Advanced Medicine โ Chicago, Illinois
- University of Kentucky - Markey Cancer Center โ Lexington, Kentucky
- LSU Health Baton Rouge โ Baton Rouge, Louisiana
- Our Lady of the Lake Cancer Institute โ Baton Rouge, Louisiana
- Tufts Medical Center โ Boston, Massachusetts
- Beth Israel Deaconess Medical Center โ Boston, Massachusetts
- Veterans Affairs Ann Arbor Healthcare System โ Ann Arbor, Michigan
- Barbara Ann Karmanos Cancer Institute โ Detroit, Michigan
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hepatocellular Carcinoma
- TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients โ Maywood, Illinois
- Cryoablation and Arterial Infusion of SD-101 in Combination With Durvalumab and Tremelimumab โ San Diego, California
- Feasibility and Efficacy of Perioperative Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular Carcinoma (HCC) โ Baltimore, Maryland
- TheraSphere With Durvalumab and Tremelimumab for HCC โ San Diego, California
- Blood Salvage in Orthotopic Liver Transplantation With HCC โ Toronto, Ontario
- Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC) โ Prescott Valley, Arizona
Explore by condition: All Hepatocellular Carcinoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.