AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies. (NCT06137144)
A Modular Phase I/II, Open-label, Multicentre Study to Evaluate the Safety, Tolerability, and Efficacy of AZD3470, a PRMT5 Inhibitor, as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies
🩺 Plain-English Summary (8th-Grade Level)
This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in combination with other anticancer agents in participants with haematologic malignancies.
Who can join: Review the eligibility criteria below.
Location: Research Site — Duarte, California
Age range: 12 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (37 Sites)
Showing the first 25 of 37 sites.
- Research Site — Duarte, California
- Research Site — Miami, Florida
- Research Site — Atlanta, Georgia
- Research Site — Boston, Massachusetts
- Research Site — Boston, Massachusetts
- Research Site — New York, New York
- Research Site — Philadelphia, Pennsylvania
- Research Site — Houston, Texas
- Research Site — Adelaide,
- Research Site — Birtinya,
- Research Site — Fitzroy,
- Research Site — Nedlands,
- Research Site — South Brisbane,
- Research Site — Waratah,
- Research Site — Beijing,
- Research Site — Guangzhou,
- Research Site — Shanghai,
- Research Site — Créteil,
- Research Site — Dijon,
- Research Site — Lille,
- Research Site — Pierre-Bénite,
- Research Site — Villejuif,
- Research Site — Berlin,
- Research Site — Cologne,
- Research Site — Erlangen,
📞 Contact the Study Coordinator
Phone: (877) 240-9479
Email: information.center@astrazeneca.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.