Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID (NCT06161688)
Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC)
🩺 Plain-English Summary (8th-Grade Level)
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be susceptible to antiviral therapy that blocks viral replication, which has the potential to alleviate long COVID symptoms. This trial will study the safety and efficacy of Ensitrelvir (S-217622), an antiviral, to treat individuals with Long COVID in an adult population.
Who can join: Review the eligibility criteria below.
Location: UCSF/Zuckerberg San Francisco General Hospital — San Francisco, California
Age range: 18 Years to 69 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UCSF/Zuckerberg San Francisco General Hospital — San Francisco, California
📞 Contact the Study Coordinator
Phone: (877) 827-3222
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Long COVID
- The Long COVID Treatment Trial — La Jolla, California
- tVNS in Long COVID-19 — New York, New York
- Nutritional Management of Post COVID-19 Cognitive Symptoms — Edmonton, Alberta
- Pain in Long COVID-19: the Role of Sleep — Boston, Massachusetts
- Long COVID Immune Profiling — Nashville, Tennessee
Explore by condition: All Long COVID clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.