A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation (NCT06200207)
Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
🩺 Plain-English Summary (8th-Grade Level)
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study medicine but does not contain any medicine). The treatment participants get is decided by chance. Participant's chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study is expected to last for up to 1 year and 4 months.
Who can join: Review the eligibility criteria below.
Location: Advanced Cardiovascular, LLC — Alexander City, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (217 Sites)
Showing the first 25 of 217 sites.
- Advanced Cardiovascular, LLC — Alexander City, Alabama
- Eastern Shore Rsrch Inst, LLC — Fairhope, Alabama
- Cardiology & Medicine Clinic — Little Rock, Arkansas
- Valley Clinical Trials, Inc. — Northridge, California
- UCI Health — Orange, California
- South California Heart Spc — Pasadena, California
- Clearwater Cardiovascular Consultants — Largo, Florida
- Ocala Cardiovascular Research — Ocala, Florida
- Ormond Beach Clinical Research — Ormond Beach, Florida
- St Johns Ctr Clin Rsch-St. Aug — Saint Augustine, Florida
- GA Arrhythmia Cons & Rsch Inst — Macon, Georgia
- Velocity Clin Rsrch - Savannah — Savannah, Georgia
- Chicago Medical Research LLC — Hazel Crest, Illinois
- UofL Health Care Outpatient — Louisville, Kentucky
- Maryland Cardiovascular Specialists - Baltimore — Baltimore, Maryland
- MD Medical Research — Oxon Hill, Maryland
- Cardio and Vascular Assoc-CAVA — Bloomfield Hills, Michigan
- Millennium Cardiology — Farmington Hills, Michigan
- Kansas City VA Medical Center — Kansas City, Missouri
- Washington University — St Louis, Missouri
- Renown Regional Medical Center — Reno, Nevada
- Long Island Cardiovascular Consultants PC — Lake Success, New York
- Mount Sinai Hosp at NYC — New York, New York
- Northwell Health Phys Cardio — Riverhead, New York
- University Of North Carolina At Chapel Hill — Chapel Hill, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure
- REDUCE LAP-HFREF TRIAL — New York, New York
- Physiological Effects Ketone Ester in Heart — Cleveland, Ohio
- DASH Diet in Heart Failure Outpatients — Sacramento, California
- Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients — Huntsville, Alabama
- LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. — Birmingham, Alabama
Explore by condition: All Heart Failure clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.