Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis (NCT06290934)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Study Evaluating the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to learn if emvistegrast (formerly GS-1427) is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with emvistegrast with participants treated with placebo. The primary objective of this study is to assess the efficacy of emvistegrast, compared with placebo control, in achieving clinical response at Week 12.
Who can join: Review the eligibility criteria below.
Location: Onyx Clinical Research (Clinic Location) — Peoria, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (181 Sites)
Showing the first 25 of 181 sites.
- Onyx Clinical Research (Clinic Location) — Peoria, Arizona
- Om Research LLC — Camarillo, California
- VVCRD Research — Garden Grove, California
- 310 Clinical Research — Inglewood, California
- US San Diego Health System — La Jolla, California
- Om Research LLC — Lancaster, California
- UCSF Benioff Children's Hospital Oakland — Oakland, California
- University Of California, Davis — Sacramento, California
- SDG Clinical Research, LLC — San Diego, California
- Acclaim Clinical Research — San Diego, California
- Peak Gastroenterology Associates — Colorado Springs, Colorado
- Peak Gastroenterology Associates — Colorado Springs, Colorado
- Gastro Florida — Clearwater, Florida
- Best Quality Research, Inc — Hialeah, Florida
- United Research Institute LLC — Hialeah, Florida
- University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center(Drug shipment)-Research Pharmacy — Miami, Florida
- Medical Professional Clinical Research Center, Inc. — Miami, Florida
- Blessed Health Care & Research, Inc — Miami, Florida
- Alliance Clinical Research of Tampa, LLC — New Port Richey, Florida
- Digestive and Liver Center of Florida, LLC — Orlando, Florida
- Clinical Research of Osceola — Orlando, Florida
- Encore Medical Research of Weston, LLC — Weston, Florida
- EBGS Clinical Research Center — Snellville, Georgia
- The University of Chicago Medical Center (Duchossois Center for Advanced Medicine) — Chicago, Illinois
- Onyx Clinical Research — Peoria, Illinois
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Ulcerative Colitis
- A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001) — Dothan, Alabama
- Pharmacokinetics of IFX and TNF Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis — San Diego, California
- A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants — Eden Prairie, Minnesota
- CP101 for the Treatment of Ulcerative Colitis — Boston, Massachusetts
- A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis — Los Angeles, California
- Angiographic Delivery of AD-MSC for Ulcerative Colitis — Rochester, Minnesota
Explore by condition: All Ulcerative Colitis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.