AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2 (NCT06346392)
A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared With Investigator's Choice of Therapy in Second- or Later-Line Adult Participants With Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2 (CLARITY Gastric 01)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to measure the efficacy and safety of AZD0901 compared to Investigator's choice of therapy as 2L+ treatment for participants with advanced or metastatic gastric or GEJ adenocarcinoma expressing CLDN18.2.
Who can join: Review the eligibility criteria below.
Location: Research Site — Mobile, Alabama
Age range: 18 Years to 130 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (158 Sites)
Showing the first 25 of 158 sites.
- Research Site — Mobile, Alabama
- Research Site — Tucson, Arizona
- Research Site — Duarte, California
- Research Site — Irvine, California
- Research Site — Los Angeles, California
- Research Site — Los Angeles, California
- Research Site — Newport Beach, California
- Research Site — Washington D.C., District of Columbia
- Research Site — Hollywood, Florida
- Research Site — Orlando, Florida
- Research Site — Marietta, Georgia
- Research Site — Boise, Idaho
- Research Site — Lexington, Kentucky
- Research Site — Boston, Massachusetts
- Research Site — Ann Arbor, Michigan
- Research Site — Ann Arbor, Michigan
- Research Site — Kansas City, Missouri
- Research Site — Mineola, New York
- Research Site — New York, New York
- Research Site — New York, New York
- Research Site — New York, New York
- Research Site — Philadelphia, Pennsylvania
- Research Site — York, Pennsylvania
- Research Site — Charlottesville, Virginia
- Research Site — Fredericksburg, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03) — Baltimore, Maryland
- Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer — Baltimore, Maryland
- Study for AZD4360 in Participants With Advanced Solid Tumours — Santa Monica, California
- Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma — Tampa, Florida
Explore by condition: All Gastric Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.