Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance (NCT06351540)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index corresponds to a measure of sustained attention. A double-blind, placebo-controlled, within-subjects crossover design will be used to examine the dose-effects of THC (0, 5mg, 30mg) on oculomotor performance tasks and a sustained attention task in frequent and infrequent cannabis users. Results from the study will advance the investigators' understanding of the effect of THC and cannabis use frequency on oculomotor function and sustained attention, and will directly inform the validity of the investigators' oculomotor platform for identifying acute THC- induced impairment in frequent and infrequent users.
Who can join: Review the eligibility criteria below.
Location: Johns Hopkins Behavioral Pharmacology Research Unit — Baltimore, Maryland
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Johns Hopkins Behavioral Pharmacology Research Unit — Baltimore, Maryland
📞 Contact the Study Coordinator
Phone: (410) 550-4035
Email: dlee214@jhmi.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cannabis Use
- Characterization of Endocannabinoid and Endogenous Opioid Levels in Adolescents With Cannabis Use Disorder — Aurora, Colorado
- Feasibility/Acceptability of a Brief Motivational Intervention for Frequent/High-Intensity Cannabis Use — Seattle, Washington
- Acute Effects of Cannabis on Cognition and Affect — Pullman, Washington
- Research Investigating Drug Effects-2 (RiDE-2) — Chicago, Illinois
- Smart Talk: Cannabis Awareness and Prevention Curriculum Evaluation — Palo Alto, California
- Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis — Lexington, Kentucky
Explore by condition: All Cannabis Use clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.