Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors (NCT06445062)
A Platform Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel
Who can join: Review the eligibility criteria below.
Location: Ironwood Cancer and Research Centers — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- Ironwood Cancer and Research Centers — Chandler, Arizona
- Mayo Clinic Hospital — Phoenix, Arizona
- HonorHealth Research Institute — Scottsdale, Arizona
- UC San Diego Moores Cancer Center — La Jolla, California
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles, California
- UCLA Hematology/Oncology- Santa Monica — Los Angeles, California
- University of Colorado Hospital-Anschutz Cancer Pavilion — Aurora, Colorado
- Yale-New Haven Hospital-Yale Cancer Center — New Haven, Connecticut
- Mayo Clinic Cancer Center — Jacksonville, Florida
- Moffitt Cancer Center — Tampa, Florida
- The University of Kansas Clinical Research Center — Westwood, Kansas
- The Sidney Kimmel Comprehensive Cancer Center at John Hopkins — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Dana Farber Cancer Institute — Boston, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- Nebraska Cancer Specialists — Omaha, Nebraska
- University of Nebraska Medical Center — Omaha, Nebraska
- Atlantic Health System — Morristown, New Jersey
- Northwell Health / RJ Zuckerberg Cancer Center — Lake Success, New York
- Columbia University Medical Center — New York, New York
- Memorial Sloan Kettering Cancer Center Main Campus — New York, New York
- Duke University Medical Center — Durham, North Carolina
- University of Cincinnati Medical Center — Cincinnati, Ohio
- Stephenson Cancer Center — Oklahoma City, Oklahoma
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (480) 398-7671
Email: research@ironwoodcrc.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.