Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia (NCT06475976)
🩺 Plain-English Summary (8th-Grade Level)
Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks' postmenstrual age), the most severe disease form. This study aims to (1) generate the first empirically defined phenotype classification system for grade 3 BPD developed using a rich array of objective and quantitative cardiopulmonary diagnostic, clinical, and biological data; and (2) define the association between phenotype subgroups and neurodevelopmental and respiratory outcomes through 2 years' corrected age.
Who can join: Review the eligibility criteria below.
Location: Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
Age range: 1 Month to 1 Year
🧪 Interventions in This Study
- Chest computed tomography (CT) with angiography (DIAGNOSTIC_TEST)
- Bronchoscopy with bronchoalveolar lavage (DIAGNOSTIC_TEST)
- Echocardiography (DIAGNOSTIC_TEST)
- 24 hour esophageal pH ("potential of hydrogen") - multichannel intraluminal impedance (MII) monitoring (reflux testing) (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (267) 648-2720
Email: jensene@chop.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Bronchopulmonary Dysplasia
- Enteral High-dose DHA Supplementation on Bronchopulmonary Dysplasia in Very Preterm Infants: a Collaborative Study — Québec, Quebec
- A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants — Little Rock, Arkansas
- Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia — Gloucester, Ontario
- Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia — Palo Alto, California
- MRI in BPD Subjects — Cincinnati, Ohio
- Ventilator Pressure and Optimization of Compliance and Hemodynamics — Birmingham, Alabama
Explore by condition: All Bronchopulmonary Dysplasia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.