๐๏ธ Verified NIH Record โข Updated 2025-10-03
Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension (NCT06492291)
A Phase 3, Open-label Extension Study to Evaluate the Safety and Efficacy of MK-0616 in Adults With Hypercholesterolemia
๐ต Active, Not Recruiting Phase3 ๐ Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC
๐ฉบ Plain-English Summary (8th-Grade Level)
This is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed either study MK-0616-013 (NCT05952856), study MK-0616-017 (NCT05952869), or study MK-0616-018 (NCT06450366).
Who can join: Review the eligibility criteria below.
Location: Alliance for Multispecialty Research, LLC ( Site 0027) โ Daphne, Alabama
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (222 Sites)
Showing the first 25 of 222 sites.
- Alliance for Multispecialty Research, LLC ( Site 0027) โ Daphne, Alabama
- G&L Research ( Site 0035) โ Foley, Alabama
- Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0048) โ Phoenix, Arizona
- National Heart Institute-Research ( Site 0029) โ Beverly Hills, California
- Clinical Trials Research ( Site 0054) โ Sacramento, California
- Velocity Clinical Research, Banning ( Site 0023) โ San Bernardino, California
- Emerson Clinical Research Institute ( Site 0017) โ Washington D.C., District of Columbia
- Excel Medical Clinical Trials ( Site 0010) โ Boca Raton, Florida
- Alliance for Multispecialty Research, LLC ( Site 0037) โ Doral, Florida
- Alliance for Multispecialty Research, LLC ( Site 0056) โ Fort Myers, Florida
- Velocity Clinical Research, Hallandale Beach ( Site 0053) โ Hallandale, Florida
- Jacksonville Center for Clinical Research ( Site 0025) โ Jacksonville, Florida
- South Broward Research ( Site 0012) โ Miramar, Florida
- Progressive Medical Research ( Site 0033) โ Port Orange, Florida
- Clinical Research Trials of Florida ( Site 0006) โ Tampa, Florida
- Clinical Site Partners, LLC dba Flourish Research ( Site 0004) โ Winter Park, Florida
- East Coast Institute for Research, LLC ( Site 0020) โ Macon, Georgia
- Healthcare Research Network - Chicago ( Site 0051) โ Flossmoor, Illinois
- Synexus Clinical Research US - Evansville ( Site 0005) โ Evansville, Indiana
- Midwest Institute For Clinical Research ( Site 0052) โ Indianapolis, Indiana
- Alliance for Multispecialty Research, LLC ( Site 0001) โ Lexington, Kentucky
- L-MARC Research Center ( Site 0011) โ Louisville, Kentucky
- Velocity Clinical Research, Covington ( Site 0026) โ Covington, Louisiana
- Velocity Clinical Research Rockville ( Site 0022) โ Rockville, Maryland
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0018) โ Troy, Michigan
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypercholesterolemia
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- Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile โ Addison, Illinois
- Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia โ Clearwater, Florida
- A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia โ Anniston, Alabama
- Causes and Natural History of Dyslipidemias โ Bethesda, Maryland
Explore by condition: All Hypercholesterolemia clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.