Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart (NCT06505798)
🩺 Plain-English Summary (8th-Grade Level)
Atrial fibrillation (AF) is a common heart rhythm disorder that causes an irregular heart beat and is a cause of heart failure (HF). Treatments include drugs to slow the heart rate, anti-arrhythmic drugs or ablation of the heart to help preserve normal rhythm. A number of trials have suggested that ablation may be superior to drug treatment to reduce hospitalisations or prevent early death. However, these studies have been small and the results not applicable to the general population with AF and heart failure in the UK. This international study will compare catheter ablation and optimal medical therapy versus optimal medical therapy alone to see if catheter ablation reduces unplanned heart failure hospitalisations and death rates and improves quality of life.
Who can join: Review the eligibility criteria below.
Location: Halifax Infirmary — Halifax
Age range: 18 Years
🧪 Interventions in This Study
- Catheter Ablation (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (24 Sites)
- Halifax Infirmary — Halifax,
- Mid and South Essex NHS Foundation Trust — Basildon,
- Queen Elizabeth Hospital — Birmingham,
- Blackpool Victoria Hospital — Blackpool,
- University Hospitals Dorset NHS Foundation Trust — Bournemouth,
- Royal Papworth Hospital NHS Foundation Trust — Cambridge,
- University Hospitals Coventry and Warwickshire NHS Trust — Coventry,
- Golden Jubilee National Hospital — Glasgow,
- Hull University Teaching Hospitals NHS Trust — Hull,
- Leeds Teaching Hospitals NHS Trust — Leeds,
- Glenfield Hospital — Leicester,
- Liverpool Heart and Chest Hospital NHS Foundation Trust — Liverpool,
- Royal Brompton and Harefields Hospitals — London,
- Barts Health NHS Trust — London,
- Imperial College Healthcare NHS Trust — London,
- St George's University Hospitals NHS Foundation Trust — London,
- St Thomas' hospital — London,
- James Cook University Hosptial — Middlesbrough,
- Freeman Hospital, Royal Victoria Infirmary — Newcastle,
- Nottingham University Hospital NHS Trust — Nottingham,
- University Hospitals Plymouth NHS Trust — Plymouth,
- Queen Alexandra Hospital — Portsmouth,
- Southampton General — Southampton,
- Swansea Bay University Health Board — Swansea,
📞 Contact the Study Coordinator
Phone: 07977217787
Email: p.lambiase@ucl.ac.uk
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation (AF)
- Detection and Classification of Cardiac Rhythm and Atrial Fibrillation Using a Finger-worn Ring — La Jolla, California
- Phase-Aligned Atrial Fibrillation Mapping — Cleveland, Ohio
- Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF) — Milwaukee, Wisconsin
- AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment — Los Angeles, California
- P-wave Duration and Local Potential as Predictors of AF Recurrence Following Pulmonary Vein Isolation — Paramus, New Jersey
- Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation — Huntsville, Alabama
Explore by condition: All Atrial Fibrillation (AF) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.