๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-04-28

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA) (NCT06510816)

A Phase 3, Multicenter, Randomized, Parallel-Group, Double-Masked, 2-Arm, Sham Controlled Study of the Efficacy, Safety, and Tolerability of ANX007 (Vonaprument) Administered by Intravitreal Injection in Participants With Dry Age-Related Macular Degeneration With Geographic Atrophy

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Annexon, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with dry AMD with GA.

Who can join: Review the eligibility criteria below.

Location: Retina Macula Institute of Arizona โ€” Scottsdale, Arizona

Age range: 50 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (132 Sites)

Showing the first 25 of 132 sites.

  • Retina Macula Institute of Arizona โ€” Scottsdale, Arizona
  • Retina-Vitreous Associates Medical Group โ€” Beverly Hills, California
  • Retinal Consultants of Orange County Clinical Research Institute Inc โ€” Fullerton, California
  • Global Research Management โ€” Glendale, California
  • Retina Consultants Medical Group โ€” Modesto, California
  • Northern California Retina Vitreous Associates Medical Group, Inc. โ€” Mountain View, California
  • Retinal Consultants Medical Group โ€” Sacramento, California
  • Macula Retina Vitreous Research Institute โ€” Torrance, California
  • Bay Area Retina Associates โ€” Walnut Creek, California
  • Retina Consultants of Southern Colorado PC โ€” Colorado Springs, Colorado
  • RSC Research, LLC โ€” Denver, Colorado
  • Rand Eye Institute โ€” Deerfield Beach, Florida
  • National Ophthalmic Research Institute โ€” Fort Myers, Florida
  • Florida Retina Institute โ€” Orlando, Florida
  • Fort Lauderdale Eye Institute โ€” Plantation, Florida
  • Retina Group of Florida โ€” Sarasota, Florida
  • Retina Vitreous Associates of Florida โ€” St. Petersburg, Florida
  • East Florida Eye Institute โ€” Stuart, Florida
  • Retina Associates of Florida โ€” Tampa, Florida
  • Georgia Retina PC โ€” Marietta, Georgia
  • Retina Consultants of Hawaii โ€” โ€˜Aiea, Hawaii
  • Retina Associates Ltd โ€” Elmhurst, Illinois
  • University Retina โ€” Oak Forest, Illinois
  • Springfield Clinic LLP โ€” Springfield, Illinois
  • Wolfe Eye Clinic โ€” West Des Moines, Iowa

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—