A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy (NCT06769048)
JADE: Phase II Trial in Patients With Geographic Atrophy: A Randomized, Double-masked, Placebo-controlled, Dose-finding Study to Evaluate the Efficacy and Safety of BI 1584862
🩺 Plain-English Summary (8th-Grade Level)
This study is open to adults aged 50 years and older with geographic atrophy that was diagnosed by imaging of the retina. The purpose of this study is to find out whether a medicine called BI 1584862 improves the eyes in people with geographic atrophy and to find the most suitable dose. This study has 4 treatment groups. Participants are put into groups randomly, which means by chance. Initially participants can join a BI 1584862 and a placebo group; then more participants are put randomly in 2 additional BI 1584862 groups and a placebo group. Participants are in the study for 1 year. During this time, they visit the study site 13 times. At the visits, doctors check the severity of participants' eye disease and collect information on any health problems. They take detailed pictures of the back of the eye, the retina, with imaging methods called fundus autofluorescence (FAF), near-infrared reflectance (NIR), and optical coherence tomography (OCT). They measure areas of the retina that appear healthy (bright) or start to waste away (dark, atrophy). The changes over time are then compared between the treatment groups.
Who can join: Review the eligibility criteria below.
Location: Associated Retina Consultants — Gilbert, Arizona
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (44 Sites)
Showing the first 25 of 44 sites.
- Associated Retina Consultants — Gilbert, Arizona
- Associated Retina Consultants, Ltd. — Phoenix, Arizona
- Cameron Ria, LLC — Phoenix, Arizona
- Retina Macula Institute of Arizona — Scottsdale, Arizona
- Retina-Vitreous Associates Medical Group — Beverly Hills, California
- Global Research Management — Glendale, California
- Retina Associates of Southern California — Huntington Beach, California
- Retinal Consultants Medical Group, Inc — Modesto, California
- Northern California Retina Vitreous Associates MedicalGroup, Inc. — Mountain View, California
- Eye Research Foundation — Newport Beach, California
- Retina Consultants of San Diego — Poway, California
- Retinal Consultants Medical Group — Sacramento, California
- Bay Area Retina Associates - Walnut Creek — Walnut Creek, California
- Retina Specialists of Colorado Research, LLC — Denver, Colorado
- Coastal Eye Surgeons — Greenwich, Connecticut
- Vitreo Retinal Associates - Gainesville — Gainesville, Florida
- MedEye Associates — Miami, Florida
- Eye Associates of Pinellas — Pinellas Park, Florida
- East Florida Eye Institute — Stuart, Florida
- Center for Retina and Macular Disease — Winter Haven, Florida
- Southeast Retina Center, PC — Augusta, Georgia
- Illinois Retina Associates - Oak Park — Oak Park, Illinois
- The Eye Care Institute — Louisville, Kentucky
- Cumberland Valley Retina Consultants — Hagerstown, Maryland
- Ophthalmic Consultants of Boston — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Geographic Atrophy
- A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA) — Scottsdale, Arizona
- A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration — Bakersfield, California
- Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy — Phoenix, Arizona
- Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy — Phoenix, Arizona
- A Study in Adults With Geographic Atrophy — Bakersfield, California
Explore by condition: All Geographic Atrophy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.