PROACT Pilot Trial (NCT06564649)
A Pilot Clinical Trial to Evaluate the Feasibility and Acceptability of: A Prospective, Unblinded, Randomized-controlled, Multicenter Biomarker Intervention Trial of a Urinary CXCL10 Clinical Surveillance Program in Pediatric Kidney Transplant Recipients for Early Ascertainment and Treatment of Subclinical Allograft Inflammation and Preservation of Kidney Transplant Function
🩺 Plain-English Summary (8th-Grade Level)
Kidney transplantation is considered the best option to treat end-stage kidney disease, but the recipient's immune system may respond with rejection to the transplanted organ, leading to permanent kidney damage and failure. The current standard for rejection monitoring in transplanted recipients is regular blood creatinine testing and kidney biopsies. Creatinine doesn't detect rejection until damages had occurred, causing some amount of kidney failure, and kidney biopsies are only done at set timepoints. A new test called CXCL10 is shown to be more effective in detecting rejection from previous research and can be done as often as needed. Therefore, The investigators are doing this randomized trial to test CXCL10 as part of clinical care and to help design a larger national clinical trial in the future.
Who can join: Review the eligibility criteria below.
Location: BC Children's Hospital — Vancouver, British Columbia
Age range: 6 Months to 18 Years
🧪 Interventions in This Study
- CXCL10 Monitoring at clinical frequency (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- BC Children's Hospital — Vancouver, British Columbia
- The Children's Hospital of Winnipeg — Winnipeg, Manitoba
- The Hospital for Sick Children — Toronto, Ontario
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Kidney Transplant Rejection
- Microbiome and Immunosuppression: The Mission Study — Minneapolis, Minnesota
- Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection — Chicago, Illinois
- The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive) — Birmingham, Alabama
- AIIM Trial: Personalized Medicine Approach to Kidney Allograft Function — Gainesville, Florida
- Trifecta-Kidney cfDNA-MMDx Study — Tampa, Florida
Explore by condition: All Kidney Transplant Rejection clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.