Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation (NCT06615596)
Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation: DESTINATION Study
🩺 Plain-English Summary (8th-Grade Level)
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF). Current guidelines recommend continued anticoagulation based on stroke risk scores, even post-ablation, potentially exposing patients to unnecessary bleeding risks. This international, multicenter, randomized controlled trial aims to compare thromboembolic and bleeding event risks between patients who continue and discontinue anticoagulation after ablation. The study involves 3,160 AF patients, all free of AF recurrence within 6 months to 1 year after ablation. Smart wearable monitors will track recurrence, and patients are followed for 24 months to assess event rates. Findings may reshape anticoagulation guidelines, improving clinical practice for AF patients worldwide.
Who can join: Review the eligibility criteria below.
Location: Brigham and Women Hospital — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- Brigham and Women Hospital — Boston, Massachusetts
- Beijing Anzhen Hospital — Beijing, Beijing Municipality
- Fuwai Hospital — Beijing, Beijing Municipality
- The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong
- Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen — Shenzhen, Guangdong
- Fuwai Central China Cardiovascular Hospital — Zhengzhou, Henan
- Wuhan Asia Heart Hospital — Wuhan, Hubei
- Shanghai Chest Hospital — Shanghai, Shanghai Municipality
- Shanxi Cardiovascular Hospital (Shanxi Cardiovascular Research Institute) — Taiyuan, Shanxi
- West China Hospital, Sichuan University — Chengdu, Sichuan
- Yunnan Fuwai Cardiovascular Hospital — Kunming, Yunnan
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang
📞 Contact the Study Coordinator
Phone: (390) 112-1319
Email: ianyao@263.net.cn
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation (AF)
- Detection and Classification of Cardiac Rhythm and Atrial Fibrillation Using a Finger-worn Ring — La Jolla, California
- Phase-Aligned Atrial Fibrillation Mapping — Cleveland, Ohio
- Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF) — Milwaukee, Wisconsin
- AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment — Los Angeles, California
- P-wave Duration and Local Potential as Predictors of AF Recurrence Following Pulmonary Vein Isolation — Paramus, New Jersey
- Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation — Huntsville, Alabama
Explore by condition: All Atrial Fibrillation (AF) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.