Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis (NCT06619990)
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study in Healthy Participants Followed by a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study in Participants With Moderate-To-Severe Active Ulcerative Colitis.
🩺 Plain-English Summary (8th-Grade Level)
The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).
Who can join: Review the eligibility criteria below.
Location: Xencor Investigative Site — Scottsdale, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (90 Sites)
Showing the first 25 of 90 sites.
- Xencor Investigative Site — Scottsdale, Arizona
- Xencor Investigative Site — Bradenton, Florida
- Xencor Investigative Site — Brandon, Florida
- Xencor Investigative Site — Jacksonville, Florida
- Xencor Investigative Site — Kissimmee, Florida
- Xencor Investigative Site — Margate, Florida
- Xencor Investigative Site — Palmetto Bay, Florida
- Xencor Investigative Site — Tampa, Florida
- Xencor Investigative Site — Tampa, Florida
- Xencor Investigative Site — Louisville, Kentucky
- Xencor Investigative Site — Oxford, Mississippi
- Xencor Investigative Site — Tupelo, Mississippi
- Xencor Investigative Site — Albany, New York
- Xencor Investigative Site — Rochester, New York
- Xencor Investigative Site — Raleigh, North Carolina
- Xencor Investigative Site — Beavercreek, Ohio
- Xencor Investigative Site — Cordova, Tennessee
- Xencor Investigative Site — Cedar Park, Texas
- Xencor Investigative Site — Denton, Texas
- Xencor Investigative Site — Garland, Texas
- Xencor Investigative Site — Georgetown, Texas
- Xencor Investigative Site — Houston, Texas
- Xencor Investigative Site — Houston, Texas
- Xencor Investigative Site — Kingwood, Texas
- Xencor Investigative Site — Lubbock, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Ulcerative Colitis (UC)
- Evaluate the Safety, Tolerability, PK and PD of SAD of Intravenously Adminsterted ALTB-268 in Healthy Participants — Miami, Florida
- A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC) — Birmingham, Alabama
- A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis — Coronado, California
- A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC) — Mobile, Alabama
- Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy — Kelowna, British Columbia
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis — Miami, Florida
Explore by condition: All Ulcerative Colitis (UC) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.