Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA) (NCT06640491)
Intraosseous Vancomycin and Cefazolin vs Intravenous Administration in Primary Total Knee Arthroplasty
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does IO administration of vancomycin and cefazolin protect against perioperative exposure risks? Is there a difference in post-operative complication rates between IV and IO administration of these drugs? Participants will be randomized to receive either the standard of care IV administration of Vancomycin and Cefazolin, or the IO administration of Vancomycin and Cefazolin.
Who can join: Review the eligibility criteria below.
Location: Houston Methodist Hospital — Houston, Texas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Houston Methodist Hospital — Houston, Texas
📞 Contact the Study Coordinator
Phone: (346) 238-1603
Email: tsullivan@houstonmethodist.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Total Knee Arthroplasty
- Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty — Coon Rapids, Minnesota
- NitrX Total Knee Arthroplasty RSA — London, Ontario
- Bicruciate-retaining (2C) Total Knee Arthroplasty (TKA) Versus Posterior-stabilized (PS) Total Knee Arthroplasty (TKA) — Montreal, Quebec
- Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts — Edina, Minnesota
- Incidence of Adductor Canal Catheter Dislodgment — Toronto, Ontario
- IO Vancomycin Administration in TKA — San Diego, California
Explore by condition: All Total Knee Arthroplasty clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.