Novel Approaches to the Treatment of Hypothyroidism (NCT06731764)
🩺 Plain-English Summary (8th-Grade Level)
Hypothyroidism is a common condition, more frequent in females, associated with excess of cardiovascular risk and poor quality of life not completely abrogated by treatment with levothyroxine. There is an unmet need to define a safe, effective, and feasible regimen to be applied in large trials aimed at assessing levothyroxine/liothyronine combination therapy in patients living with hypothyroidism. To address this knowledge gap we propose a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study whose results will lay the foundation of large multicenter trial(s) able to demonstrate the effectiveness (or lack thereof) of levothyroxine/liothyronine combination therapy.
Who can join: Review the eligibility criteria below.
Location: UConn Health — Farmington, Connecticut
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UConn Health — Farmington, Connecticut
📞 Contact the Study Coordinator
Phone: (860) 679-2715
Email: celi@uchc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypothyroidism
- Gluten Free Diet in Hashimoto's Hypothyroidism — Cleveland, Ohio
- Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism — Little Rock, Arkansas
- A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants — Birmingham, Alabama
- An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets. — Modesto, California
- Dosing of LT4 in Older Individuals — Philadelphia, Pennsylvania
- Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing — San Francisco, California
Explore by condition: All Hypothyroidism clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.