A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (NCT06750094)
A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable or metastatic colorectal cancer who have previously received chemotherapy.
Who can join: Review the eligibility criteria below.
Location: Ironwood Cancer and Research Center — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (251 Sites)
Showing the first 25 of 251 sites.
- Ironwood Cancer and Research Center — Chandler, Arizona
- Banner MD Anderson Cancer Center — Gilbert, Arizona
- Arizona Oncology Associates PC NAHOA — Prescott, Arizona
- St. Bernard's Medical Center — Jonesboro, Arkansas
- Highlands Oncology Group — Springdale, Arkansas
- CBCC Global Research — Bakersfield, California
- Los Angeles Cancer Network — Glendale, California
- Cancer and Blood Specialty Clinic — Los Alamitos, California
- USC Norris Comprehensive Cancer Center — Los Angeles, California
- UCLA — Santa Monica, California
- Providence Medical Foundation — Santa Rosa, California
- Torrance Memorial Physicians Network — Torrance, California
- University of Colorado Denver Anschultz Medical Campus — Aurora, Colorado
- Rocky Mountain Cancer Centers — Denver, Colorado
- Eastern Connecticut Hematology & Oncology Assoc. — Norwich, Connecticut
- Florida Cancer Specialists South — Fort Myers, Florida
- Mount Sinai Medical Center Campus — Miami Beach, Florida
- AdventHealth Cancer Institute — Orlando, Florida
- Florida Cancer Specialists North Region — St. Petersburg, Florida
- Florida Cancer Specialists East — West Palm Beach, Florida
- University Cancer And Blood Center LLC — Athens, Georgia
- Grady Memorial Hospital — Atlanta, Georgia
- Piedmont Cancer Institute — Atlanta, Georgia
- Winship Cancer Institute Emory University — Atlanta, Georgia
- Illinois Cancer Specialists — Arlington Heights, Illinois
📞 Contact the Study Coordinator
Phone: (844) 434-4210
Email: Participate-In-This-Study1@its.jnj.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.